Gene Symbol | HAVCR2 |
---|---|
Entrez Gene | 84868 |
Alt Symbol | HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3 |
Species | Human |
Gene Type | protein-coding |
Description | hepatitis A virus cellular receptor 2 |
Other Description | T cell immunoglobulin mucin 3|T cell immunoglobulin mucin-3|T-cell immunoglobulin and mucin domain-containing protein 3|T-cell immunoglobulin mucin family member 3|T-cell immunoglobulin mucin receptor 3|T-cell membrane protein 3|kidney injury molecule-3 |
Swissprots | Q96K94 Q8WW60 Q8TDQ0 B2RAY2 |
Accessions | CAH05307 EAW61613 EAW61614 Q8TDQ0 AB924452 BAQ00263 AF251707 AAM19100 AF450242 AAL65157 AF450243 AAL65158 AK027334 BAB55044 AK130144 AK314406 BAG37029 AY069944 AAL55401 BC020843 AAH20843 BC063431 AAH63431 BP291914 HQ448118 ADQ32599 JX049979 AFO66593 NM_032782 NP_116171 |
Function | Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. {ECO:0000269|PubMed:14556005, ECO:0000269|PubMed:16286920}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | T-helper type 1 lymphocyte (Th1)-specific. |