| Gene Symbol |
RNF169
|
| Entrez Gene |
254225
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 169
|
| Other Description |
E3 ubiquitin-protein ligase RNF169
|
| Swissprots |
Q8NCN4 Q6N015
|
| Accessions |
EAW74947 Q8NCN4 AB082522 BAC02700 BC169205 AAI69205 BU735906 BX640750 CAE45858 DQ580376 DQ600280 XM_011544889 XP_011543191 XM_011544890 XP_011543192 NM_001098638 NP_001092108
|
| Function |
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833}.
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833}. Note=Localizes to sites of double- strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products.
|