RNF169

Gene Symbol RNF169
Entrez Gene 254225
Alt Symbol -
Species Human
Gene Type protein-coding
Description ring finger protein 169
Other Description E3 ubiquitin-protein ligase RNF169
Swissprots Q8NCN4 Q6N015
Accessions EAW74947 Q8NCN4 AB082522 BAC02700 BC169205 AAI69205 BU735906 BX640750 CAE45858 DQ580376 DQ600280 XM_011544889 XP_011543191 XM_011544890 XP_011543192 NM_001098638 NP_001092108
Function Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833}. Note=Localizes to sites of double- strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products.

Human RNF169 protein fragment - ab166030 from Abcam

Category Protein
Source Wheat germ
Species Human
ab166030 on a 12.5% SDS-PAGE stained with Coomassie Blue.

RNF169 Antibody Blocking Peptide - LS-E16010 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human RNF169 Protein - H00254225-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

RNF169 Blocking Peptide - 33R-2192 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

RNF169 - H00254225-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

RNF169 - H00254225-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Recombinant Human RING finger protein 169(RNF169) - CSB-YP019855HU CSB-EP019855HU CSB-BP019855HU CSB-MP019855HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

RNF169 Protein - NBP2-13239PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

RNF169 Peptide, Human - M34GP13402H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

RNF169 Recombinant Protein Antigen - NBP2-58205PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

RING finger protein 169 (RNF169), Recombinant Protein - MBS1384676 from MyBioSource

Category Protein
Prices $1,515.00, $1,515.00, $1,745.00, $1,745.00, $2,595.00, $2,595.00, $3,040.00, $3,040.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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