RNF169

Gene Symbol RNF169
Entrez Gene 254225
Alt Symbol -
Species Human
Gene Type protein-coding
Description ring finger protein 169
Other Description E3 ubiquitin-protein ligase RNF169
Swissprots Q8NCN4 Q6N015
Accessions EAW74947 Q8NCN4 AB082522 BAC02700 BC169205 AAI69205 BU735906 BX640750 CAE45858 DQ580376 DQ600280 XM_011544889 XP_011543191 XM_011544890 XP_011543192 NM_001098638 NP_001092108
Function Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833}. Note=Localizes to sites of double- strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products.

RNF169 (A-20) - sc-248466 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RNF169 (L-20) - sc-248467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RNF169 antibody - ab87711 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RNF169 antibody (ab87711) at 1 µg/ml (in 5% skim milk / PBS buffer) + THP-1 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 50000

Anti-RNF169 antibody - ab188237 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RNF169 antibody (ab188237) at 1/2000 dilutionLane 1 : U2OS cell lysate (si RNA control)Lane 2 : U2OS cell lysate (si RNA RNF169 transfected)Lane 3 : NIH-3T3 cell lysateLane 4 : INS-1 cell lysateLysates/proteins at 40 µg per lane.

Anti-RNF169 Antibody (aa200-250) - LS-C290741 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF169 Antibody (aa325-375) - LS-C290742 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF169 Antibody (aa215-264) - LS-C110794 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RNF169 antibody LS-C110794 Western blot of THP-1 cell lysate.

RNF169 Antibody - NBP1-55084 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RNF169 Antibody [NBP1-55084] - THP-1 cell lysate, concentration 0.2-1 ug/ml.

RNF169 Antibody - NBP2-13239 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: RNF169 Antibody [NBP2-13239] - Staining of human oral mucosa shows moderate nuclear positivity in squamous epithelial cells.

RNF169 Antibody - H00254225-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

RNF169 Polyclonal Antibody - bs-9259R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded Mouse heart tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with RNF169 Polyclonal Antibody, Unconjugated (bs-9259R) at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining

Anti-RNF169 antibody produced in rabbit - HPA046138 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RNF169:<B>Cat. No. HPA046138</B>: Immunohistochemical staining of human oral mucosa shows moderate nuclear positivity in squamous epithelial cells.

Anti-RNF169, (N-terminal) antibody produced in rabbit - SAB2103543 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RNF169, antibody produced in rabbit: <B>Cat. No. SAB2103543</B>: Immunoblotting analysis of RNF169 in THP-1 cell lysate with RNF169 anitbody at 1 μg/mL.

RNF169 antibody - N-terminal region (ARP43508_P050) - ARP43508_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RNF169 antibody (FITC) - orb4105 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

RNF169 antibody - 70R-2824 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

RNF169 antibody - H00254225-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

RNF169 antibody - H00254225-M01A from Acris Antibodies

Prices $360.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 3B6

RNF169 Antibody - 31-285 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Antibody used in WB on Human THP-1 at 0.2-1 ug/ml.

RNF169 Antibody - GWB-MP503H from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RNF169 (aa 643-742) polyclonal antibody - DPAB-DC1201 from Creative Diagnostics

Host Mouse
Clonality Polyclonal

RNF169 Antibody - A304-097A from Bethyl Labs

Prices $99.00, $339.00
Sizes 10 µl (1 mg/ml), 100 µl (1 mg/ml)
Host Rabbit
Clonality Polyclonal

RNF169 Antibody - A304-098A from Bethyl Labs

Prices $99.00, $339.00
Sizes 10 µl (1 mg/ml), 100 µl (1 mg/ml)
Host Rabbit
Clonality Polyclonal

RNF169 Antibody AbVantage™ Pack - A311-473A from Bethyl Labs

Prices $472.00
Sizes 1 pack
Host Rabbit
Clonality Polyclonal

Anti-RNF169 monoclonal antibody, clone 4C7 - DCABH-16712 from Creative Diagnostics

Host Mouse
Clonality Monoclonal
Clone 4C7
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