| Gene Symbol |
Pick1
|
| Entrez Gene |
18693
|
| Alt Symbol |
Prkcabp
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
protein interacting with C kinase 1
|
| Other Description |
PRKCA-binding protein|protein kinase C-alpha-binding protein|protein that interacts with C kinase 1
|
| Swissprots |
Q62083 E9PY04
|
| Accessions |
EDL04663 EDL04664 EDL04665 EDL04666 EDL04667 Q62083 AI385692 AI893973 AK050224 AK090155 BAC41117 AK162724 AK177140 BC023088 BC030363 BC030880 BC030912 BC040824 BC048788 AAH48788 BE652516 BU057774 BU698586 CA468666 CD363874 CK791908 Z46720 CAA86675 XM_006520603 XP_006520666 XM_006520604 XP_006520667 XM_006520605 XP_006520668 XM_006520606 XP_006520669 XM_006520607 XP_006520670 NM_001045558 NP_001039023 NM_008837 NP_032863
|
| Function |
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:1497
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane {ECO:0000269|PubMed:24068808}; Lipid-anchor {ECO:0000269|PubMed:24068808}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all tissues examined, with highest levels in brain and testes and lowest levels in lung.
|