| Gene Symbol | Pick1 |
|---|---|
| Entrez Gene | 18693 |
| Alt Symbol | Prkcabp |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | protein interacting with C kinase 1 |
| Other Description | PRKCA-binding protein|protein kinase C-alpha-binding protein|protein that interacts with C kinase 1 |
| Swissprots | Q62083 E9PY04 |
| Accessions | EDL04663 EDL04664 EDL04665 EDL04666 EDL04667 Q62083 AI385692 AI893973 AK050224 AK090155 BAC41117 AK162724 AK177140 BC023088 BC030363 BC030880 BC030912 BC040824 BC048788 AAH48788 BE652516 BU057774 BU698586 CA468666 CD363874 CK791908 Z46720 CAA86675 XM_006520603 XP_006520666 XM_006520604 XP_006520667 XM_006520605 XP_006520668 XM_006520606 XP_006520669 XM_006520607 XP_006520670 NM_001045558 NP_001039023 NM_008837 NP_032863 |
| Function | Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:1497 |
| Subcellular Location | Cytoplasm, perinuclear region {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane {ECO:0000269|PubMed:24068808}; Lipid-anchor {ECO:0000269|PubMed:24068808}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}. |
| Tissue Specificity | Expressed in all tissues examined, with highest levels in brain and testes and lowest levels in lung. |
PICK1 CRISPR/Cas9 KO Plasmid (m) - sc-422225 from Santa Cruz Biotechnology
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PICK1 HDR Plasmid (m) - sc-422225-HDR from Santa Cruz Biotechnology
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PICK1 Double Nickase Plasmid (m) - sc-422225-NIC from Santa Cruz Biotechnology
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PICK1 Double Nickase Plasmid (m2) - sc-422225-NIC-2 from Santa Cruz Biotechnology
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PICK1 CRISPR Activation Plasmid (m) - sc-422225-ACT from Santa Cruz Biotechnology
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PICK1 CRISPR Activation Plasmid (m2) - sc-422225-ACT-2 from Santa Cruz Biotechnology
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PICK1 Lentiviral Activation Particles (m) - sc-422225-LAC from Santa Cruz Biotechnology
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PICK1 Lentiviral Activation Particles (m2) - sc-422225-LAC-2 from Santa Cruz Biotechnology
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PICK1 siRNA (m) - sc-36222 from Santa Cruz Biotechnology
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PICK1 shRNA Plasmid (m) - sc-36222-SH from Santa Cruz Biotechnology
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PICK1 shRNA (m) Lentiviral Particles - sc-36222-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN38696 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38696 from Sigma-Aldrich
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shRNA set against Mouse PICK1 (NM_008837.2) - SHH375316 from Creative biogene
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shRNA set against Mouse Pick1(NM_001045558.1) - SHR113352 from Creative biogene
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shRNA set against Mouse Pick1(NM_008837.2) - SHR113388 from Creative biogene
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PICK1 miRNA 3'UTR clone - MiUTR1M-09189 from Creative biogene
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