| Gene Symbol |
PARD6A
|
| Entrez Gene |
50855
|
| Alt Symbol |
PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
par-6 family cell polarity regulator alpha
|
| Other Description |
PAR-6 alpha|Tax-interacting protein 40|par-6 partitioning defective 6 homolog alpha|partitioning defective 6 homolog alpha|partitioning defective-6 homolog alpha|partitioning-defective protein 6|tax interaction protein 40
|
| Swissprots |
O14911 Q9NPB6 Q9NPJ7
|
| Accessions |
EAW83151 Q9NPB6 AB041642 BAB16105 AB043634 BAA96235 AF028827 AAB84252 AF252292 AAF71529 AF265565 AAF75548 AJ277095 CAB85490 BC015626 AAH15626 DQ893477 ABM84403 DQ896347 ABM87346 XM_005255977 XP_005256034 XM_011523095 XP_011521397 XM_011523096 XP_011521398 NM_001037281 NP_001032358 NM_016948 NP_058644
|
| Function |
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. {ECO:0000269|PubMed:10873802}.
|
| Subcellular Location |
Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Note=Colocalizes with GTP- bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.
|
| Tissue Specificity |
Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
|
| Top Pathways |
Tight junction, Endocytosis, Hippo signaling pathway, Rap1 signaling pathway
|