PARD6A

Gene Symbol PARD6A
Entrez Gene 50855
Alt Symbol PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40
Species Human
Gene Type protein-coding
Description par-6 family cell polarity regulator alpha
Other Description PAR-6 alpha|Tax-interacting protein 40|par-6 partitioning defective 6 homolog alpha|partitioning defective 6 homolog alpha|partitioning defective-6 homolog alpha|partitioning-defective protein 6|tax interaction protein 40
Swissprots O14911 Q9NPB6 Q9NPJ7
Accessions EAW83151 Q9NPB6 AB041642 BAB16105 AB043634 BAA96235 AF028827 AAB84252 AF252292 AAF71529 AF265565 AAF75548 AJ277095 CAB85490 BC015626 AAH15626 DQ893477 ABM84403 DQ896347 ABM87346 XM_005255977 XP_005256034 XM_011523095 XP_011521397 XM_011523096 XP_011521398 NM_001037281 NP_001032358 NM_016948 NP_058644
Function Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. {ECO:0000269|PubMed:10873802}.
Subcellular Location Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Note=Colocalizes with GTP- bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.
Tissue Specificity Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
Top Pathways Tight junction, Endocytosis, Hippo signaling pathway, Rap1 signaling pathway

PARD6A-Over-expression-Lysate - LY14018a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PARD6A (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PARD6A gene.

PARD6A 293T Cell Transient Overexpression Lysate(Denatured) - H00050855-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

PARD6A overexpression lysate - LY421938 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

PARD6A 293 Cell Lysate - 409604 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Species C. elegans

PARD6A Overexpression Lysate (Denatured) - H00050855-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
PARD6A transfected lysate

PARD6A Overexpression Lysate (Native) - NBL1-14102 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: PAR6 Overexpression Lysate (Adult Normal) [NBL1-14102] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PAR6.

PARD6A (h): 293T Lysate - sc-173794 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

PARD6A Over-expression Lysate Product - GWB-CCAC50 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

PARD6A Overexpression Lysate (Denatured) - H00050855-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human PARD6A Knockdown Stable Cell Line - CSC-DC011303 from Creative biogene

Category Cell Line
Species Human
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