PARD6A

Gene Symbol PARD6A
Entrez Gene 50855
Alt Symbol PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40
Species Human
Gene Type protein-coding
Description par-6 family cell polarity regulator alpha
Other Description PAR-6 alpha|Tax-interacting protein 40|par-6 partitioning defective 6 homolog alpha|partitioning defective 6 homolog alpha|partitioning defective-6 homolog alpha|partitioning-defective protein 6|tax interaction protein 40
Swissprots O14911 Q9NPB6 Q9NPJ7
Accessions EAW83151 Q9NPB6 AB041642 BAB16105 AB043634 BAA96235 AF028827 AAB84252 AF252292 AAF71529 AF265565 AAF75548 AJ277095 CAB85490 BC015626 AAH15626 DQ893477 ABM84403 DQ896347 ABM87346 XM_005255977 XP_005256034 XM_011523095 XP_011521397 XM_011523096 XP_011521398 NM_001037281 NP_001032358 NM_016948 NP_058644
Function Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. {ECO:0000269|PubMed:10873802}.
Subcellular Location Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Note=Colocalizes with GTP- bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.
Tissue Specificity Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
Top Pathways Tight junction, Endocytosis, Hippo signaling pathway, Rap1 signaling pathway

PARD6A (C-3) - sc-365323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PARD6A (C-3): sc-365323. Western blot analysis of PARD6A expression in non-transfected: sc-117752 (A) and human PARD6A transfected: sc-173794 (B) 293T whole cell lysates.

PARD6A (G-9) - sc-74479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PARD6A (G-9): sc-74479. Western blot analysis of PARD6A expression in MIA PaCa-2 whole cell lysate.

PARD6A (H-18) - sc-14403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PARD6A (H-18): sc-14403. Western blot analysis of PARD6A expression in non-transfected: sc-117752 (A) and human PARD6A transfected: sc-173794 (B) 293T whole cell lysates.

PARD6A (H-90) - sc-25525 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PARD6A (H-90): sc-25525. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

PARD6A (N-18) - sc-14401 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PARD6A Antibody (N-18): sc-14401. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic and nuclear staining of glandular cells.

PARD6A (T-20) - sc-14405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PARD6A (T-20): sc-14405. Immunofluorescence staining of methanol-fixed Y79 cells showing membrane localization.

PARD6A/B (S-19) - sc-33898 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PARD6A/B (S-19): sc-33898. Western blot analysis of PARD6A/B expression in 293T whole cell lysate.

Anti-PAR6 antibody - ab49776 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PAR6 antibody (ab49776) at 1 µg/ml + PARD6A partial Human Recombinant Tagged Protein at 0.2 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-PAR6 antibody - ab6022 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Ab6022 (10ug/ml) staining human PAR6 in human pancreas by immunohistochemistry using paraffin embedded tissue. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining. Ab6022 shows strong cytoplasmic staining in rare cells of intralobular ducts.

Anti-PAR6 antibody - ab115612 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115612 (10 ug/ml) staining PAR6 in Paraffin-embedded Human Pancreas tissue by Immunihistochemistry ( Microwaved antigen retrieval with Tris/EDTA buffer pH9), HRP staining.

Anti-PAR6 antibody - ab111823 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PAR6 antibody - ab195984 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAR6 antibody [EPR12378] - N-terminal - ab180159 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12378
All lanes : Anti-PAR6 antibody [EPR12378] - N-terminal (ab180159) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Fetal liver lysateLane 3 : 293T cell lysateLane 4 : Jurkat cell lysateLane 5 : Y79 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilutiondeveloped using the ECL technique

Anti-PAR6 antibody - Aminoterminal end - ab53227 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAR6 antibody - C-terminal - ab194506 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-PAR6 antibody - C-terminal (ab194506) at 1/1000 dilution + recombinant Human PAR6 protein (immunogen) at 0.2 µgdeveloped using the ECL technique

Anti-PAR6 antibody - C-terminal - ab171026 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PAR6 antibody - C-terminal (ab171026) at 1 µg/ml + Mouse Thymus lysate at 10 µg

Anti-PAR6 antibody - Carboxyterminal end - ab53228 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAR6 Antibody (N-Terminus) - LS-C144657 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PAR6 Antibody (C-Terminus) - LS-C155157 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PAR6 Antibody (C-Terminus) - LS-C144658 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PARD6A / PAR6 Antibody (Internal) - LS-C145105 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PARD6A / PAR6 Antibody - LS-C341529 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PARD6A / PAR6 Antibody (C-Terminus) - LS-C210161 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-PARD6A / PAR6 Antibody (N-Terminus) - LS-C110723 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PARD6A / PAR6 antibody LS-C110723 Western blot of NCI-H226 cell lysate.

Anti-PARD6A / PAR6 Antibody (aa251-300) - LS-C170195 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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