UCHL1

Gene Symbol	UCHL1
Entrez Gene	7345
Alt Symbol	HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
Species	Human
Gene Type	protein-coding
Description	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Other Description	epididymis luminal protein 117|neuron cytoplasmic protein 9.5|ubiquitin C-terminal hydrolase|ubiquitin carboxyl-terminal hydrolase isozyme L1|ubiquitin thioesterase L1
Swissprots	Q4W5K6 P09936 Q71UM0
Accessions	AAY40923 ACY95405 CAA35249 EAW92978 EAW92979 EAW92980 EAW92981 EAW92982 EAW92983 P09936 AB209038 BAD92275 AK054579 BAG51393 AK315368 BAG37761 BC000332 AAH00332 BC005117 AAH05117 BC006305 AAH06305 BC018838 BP202166 DQ891998 ABM82924 DQ895188 ABM86114 FJ224355 ACI46047 X04741 CAA28443 NM_004181 NP_004172
Function	Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. {ECO:0000269|PubMed:12408865, ECO:0000269|PubMed:9790970}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19261853}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19261853}; Lipid-anchor {ECO:0000269|PubMed:19261853}. Note=About 30% of total UCHL1 is associated with membranes in brain.
Tissue Specificity	Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. {ECO:0000269|PubMed:14722078, ECO:0000269|PubMed:9790970}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UCHL1 / PGP9.5 ELISA Kit - LS-F6691 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156 - 10 ng/ml

Rat UCHL1 / PGP9.5 ELISA Kit - LS-F7093 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 33 pg/ml Range 78.125 - 5000 pg/ml

Mouse/Human/Rat UCHL1 / PGP9.5 ELISA Kit (Cell-Based ELISA) - LS-F2239 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 78-5000 pg/ml

Mouse UCHL1 / PGP9.5 ELISA Kit - LS-F9647 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 25 pg/ml Range 78.125 - 5000 pg/ml

Pig UCHL1 / PGP9.5 ELISA Kit (Sandwich ELISA) - LS-F12898 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 15.6 Range 78-5000 pg/ml

Human UCHL1 / PGP9.5 ELISA Kit (Sandwich ELISA) - LS-F12897 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78-5000 pg/ml

Protein Gene Product 9.5 (PGP 9.5), Human, ELISA Kit - CSB-E13238h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 15.6 ng/ml Range 62.5 ng/ml-4000 ng/ml

Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1), Human, ELISA Kit - SEG945Hu from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t Sensitivity 0.056ng/mL Range 0.156-10ng/mL

Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCHL1, Human, ELISA Kit - E1741h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

Ubiquitin Carboxyl Terminal Hydrolase L1, UCHL1, Human, ELISA Kit - E-EL-H2377 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

Ubiquitin Carboxyl Terminal Hydrolase L1, UCHL1, Rabbit, ELISA Kit - E-EL-RB1084 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Carboxyl Terminal Hydrolase L1, UCHL1, Chicken, ELISA Kit - E-EL-Ch1466 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ubiquitin Carboxyl Terminal Hydrolase L1, UCHL1, Porcine, ELISA Kit - E-EL-P1000 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Carboxyl Terminal Hydrolase L1, UCHL1, Guinea Pig, ELISA Kit - E-EL-GP0413 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ubiquitin Carboxyl Terminal Hydrolase L1, UCHL1, Monkey, ELISA Kit - E-EL-MK0426 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PGP9.5 Colorimetric Cell-Based ELISA Kit - CB5551 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human UCHL1(Ubiquitin Carboxyl Terminal Hydrolase L1) ELISA Kit - E-EL-H2377 from Elabscience Category ELISA Kit Sensitivity 46.88 pg/mL Range 78.13—5000 pg/mL

Human UCHL1 (Ubiquitin Carboxyl Terminal Hydrolase L1) CLIA Kit - E-CL-H1382 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

Ubiquitin Carboxyl Terminal Hydrolase L1, ELISA Kit - MBS048133 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl Terminal Hydrolase L1, ELISA Kit - MBS080655 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0 pg/ml. Range 31.2 pg/ml - 1000 pg/ml.

Ubiquitin Carboxyl Terminal Hydrolase L1, ELISA Kit - MBS085783 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl Terminal Hydrolase L1, ELISA Kit - MBS101686 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl Terminal Hydrolase L1, ELISA Kit - MBS089175 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl Terminal Hydrolase L1, ELISA Kit - MBS055914 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Carboxyl Terminal Hydrolase L1, ELISA Kit - MBS091018 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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