UCHL1

Gene Symbol	UCHL1
Entrez Gene	7345
Alt Symbol	HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
Species	Human
Gene Type	protein-coding
Description	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Other Description	epididymis luminal protein 117|neuron cytoplasmic protein 9.5|ubiquitin C-terminal hydrolase|ubiquitin carboxyl-terminal hydrolase isozyme L1|ubiquitin thioesterase L1
Swissprots	Q4W5K6 P09936 Q71UM0
Accessions	AAY40923 ACY95405 CAA35249 EAW92978 EAW92979 EAW92980 EAW92981 EAW92982 EAW92983 P09936 AB209038 BAD92275 AK054579 BAG51393 AK315368 BAG37761 BC000332 AAH00332 BC005117 AAH05117 BC006305 AAH06305 BC018838 BP202166 DQ891998 ABM82924 DQ895188 ABM86114 FJ224355 ACI46047 X04741 CAA28443 NM_004181 NP_004172
Function	Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. {ECO:0000269|PubMed:12408865, ECO:0000269|PubMed:9790970}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19261853}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19261853}; Lipid-anchor {ECO:0000269|PubMed:19261853}. Note=About 30% of total UCHL1 is associated with membranes in brain.
Tissue Specificity	Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. {ECO:0000269|PubMed:14722078, ECO:0000269|PubMed:9790970}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® UCHL1 siRNA I - 12353 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® UCHL1 siRNA II - 12415 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

UCH-L1 CRISPR/Cas9 KO Plasmid (h) - sc-401088 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L1 HDR Plasmid (h) - sc-401088-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L1 Double Nickase Plasmid (h) - sc-401088-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L1 Double Nickase Plasmid (h2) - sc-401088-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L1 CRISPR Activation Plasmid (h) - sc-401088-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L1 CRISPR Activation Plasmid (h2) - sc-401088-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L1 Lentiviral Activation Particles (h) - sc-401088-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L1 Lentiviral Activation Particles (h2) - sc-401088-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L1 siRNA (h) - sc-42304 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UCH-L1 shRNA Plasmid (h) - sc-42304-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UCH-L1 shRNA (h) Lentiviral Particles - sc-42304-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UCH-L1/PGP9.5 RNAi - H00007345-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU021911 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22434 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22434 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02673 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02673

UCHL1 siRNA (Human) - CRH5021 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UCHL1 - MBS8223408 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human UCHL1 (NM_004181.4) - SHH439752 from Creative biogene Category siRNA Species Reactivities Human

UCH-L1 CRISPR/Cas9 KO Plasmid (h2) - sc-401088-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UCH-L1 HDR Plasmid (h2) - sc-401088-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UCHL1 shRNA Plasmid (Human) - CHH5021 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UCHL1 miRNA 3'UTR clone - MiUTR3H-02368 from Creative biogene Species Reactivities Human

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