| Gene Symbol |
UCHL1
|
| Entrez Gene |
7345
|
| Alt Symbol |
HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
|
| Other Description |
epididymis luminal protein 117|neuron cytoplasmic protein 9.5|ubiquitin C-terminal hydrolase|ubiquitin carboxyl-terminal hydrolase isozyme L1|ubiquitin thioesterase L1
|
| Swissprots |
Q4W5K6 P09936 Q71UM0
|
| Accessions |
AAY40923 ACY95405 CAA35249 EAW92978 EAW92979 EAW92980 EAW92981 EAW92982 EAW92983 P09936 AB209038 BAD92275 AK054579 BAG51393 AK315368 BAG37761 BC000332 AAH00332 BC005117 AAH05117 BC006305 AAH06305 BC018838 BP202166 DQ891998 ABM82924 DQ895188 ABM86114 FJ224355 ACI46047 X04741 CAA28443 NM_004181 NP_004172
|
| Function |
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. {ECO:0000269|PubMed:12408865, ECO:0000269|PubMed:9790970}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19261853}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19261853}; Lipid-anchor {ECO:0000269|PubMed:19261853}. Note=About 30% of total UCHL1 is associated with membranes in brain.
|
| Tissue Specificity |
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. {ECO:0000269|PubMed:14722078, ECO:0000269|PubMed:9790970}.
|
