UCHL1

Gene Symbol	UCHL1
Entrez Gene	7345
Alt Symbol	HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
Species	Human
Gene Type	protein-coding
Description	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Other Description	epididymis luminal protein 117|neuron cytoplasmic protein 9.5|ubiquitin C-terminal hydrolase|ubiquitin carboxyl-terminal hydrolase isozyme L1|ubiquitin thioesterase L1
Swissprots	Q4W5K6 P09936 Q71UM0
Accessions	AAY40923 ACY95405 CAA35249 EAW92978 EAW92979 EAW92980 EAW92981 EAW92982 EAW92983 P09936 AB209038 BAD92275 AK054579 BAG51393 AK315368 BAG37761 BC000332 AAH00332 BC005117 AAH05117 BC006305 AAH06305 BC018838 BP202166 DQ891998 ABM82924 DQ895188 ABM86114 FJ224355 ACI46047 X04741 CAA28443 NM_004181 NP_004172
Function	Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. {ECO:0000269|PubMed:12408865, ECO:0000269|PubMed:9790970}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19261853}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19261853}; Lipid-anchor {ECO:0000269|PubMed:19261853}. Note=About 30% of total UCHL1 is associated with membranes in brain.
Tissue Specificity	Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. {ECO:0000269|PubMed:14722078, ECO:0000269|PubMed:9790970}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UCHL1 gene - orb92684 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-UCHL1-cDNA-Clone - DC00145 from Abgent, a WuXi AppTec company Prices $301.05 Sizes 10 µg Species Human Accession NM_004181

UCHL1 - MBS1267853 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC000332

Human UCHL1 ORF Clone(NM_004181.4) - CDCL180420 from Creative Biomart Species Human Accession NM_004181.4

Human UCHL1 ORF Clone(NM_004181.4) - CDCL180421 from Creative Biomart Species Human Accession NM_004181.4

Human UCHL1 ORF clone(NM_004181.4) - CDCL186670 from Creative Biomart Species Human Accession NM_004181.4

Human UCHL1 Gene ORF cDNA clone in cloning vector - HG11663-M from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11663-NF from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11663-ANG from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11663-ACG from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11663-CF from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11663-NM from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11663-NY from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11663-CM from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11663-NH from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid - HG11663-UT from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11663-CH from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11663-CY from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11663-M-F from Sino Biological Species Human

Human UCHL1 ORF clone(NM_004181.4) - CDCL186670 from Creative biogene Species Human

Human UCHL1 ORF Clone (BC000332) - CDCS411660 from Creative biogene Species Human Accession P09936

Human UCHL1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11663-ACR from Sino Biological Species Human

Human UCHL1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11663-ANR from Sino Biological Species Human

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