| Gene Symbol |
ARHGAP35
|
| Entrez Gene |
2909
|
| Alt Symbol |
GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho GTPase activating protein 35
|
| Other Description |
glucocorticoid receptor DNA binding factor 1|glucocorticoid receptor DNA-binding factor 1|glucocorticoid receptor repression factor 1|rho GAP p190A|rho GTPase-activating protein 35
|
| Swissprots |
Q9C0E1 A7E2A4 Q14452 Q9NRY4
|
| Accessions |
EAW57450 EAW57451 EAW57452 EAW57453 Q9NRY4 AB051509 BAB21813 AF159851 AAF80386 AK096123 AK097314 AK298356 BAG60600 AL831914 BC003514 BC065491 BC131565 AAI31566 BC150257 AAI50258 BE871213 BM855708 CA429690 CX163309 M73077 AAA58618 XM_011526873 XP_011525175 XR_935811 NM_004491 NP_004482 NM_024342
|
| Function |
Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'- GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor. {ECO:0000269|PubMed:1894621}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Top Pathways |
Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton
|