AIFM2

Gene Symbol AIFM2
Entrez Gene 84883
Alt Symbol AMID, PRG3
Species Human
Gene Type protein-coding
Description apoptosis-inducing factor, mitochondrion-associated, 2
Other Description apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death|apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death|apoptosis-inducing factor 2|p53-responsive gene 3 protein
Swissprots Q63Z39 B3KXI0 Q9BRQ8
Accessions CAE90404 EAW54376 Q9BRQ8 AF337957 AAL73229 AF506757 AAM77596 AI922797 AK027403 BAB55089 AK127353 BAG54492 BC006121 AAH06121 BC023601 AAH23601 BG332787 BP331371 BX537621 CAH56481 DQ893092 ABM84018 DQ896364 ABM87363 NM_032797 NP_116186 NM_001198696 NP_001185625
Function Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:12135761, ECO:0000269|PubMed:15958387}.
Subcellular Location Cytoplasm. Mitochondrion outer membrane.
Tissue Specificity Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. {ECO:0000269|PubMed:12135761}.

AMID (B-6) - sc-377120 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AMID (B-6): sc-377120. Western blot analysis of AMID expression in Hep G2 whole cell lysate.

AMID (E-1) - sc-376987 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AMID (E-1): sc-376987. Western blot analysis of AMID expression in Hep G2 whole cell lysate.

AMID (E-17) - sc-54161 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

AMID (H-300) - sc-135000 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AMID (H-300): sc-135000. Western blot analysis of AMID expression in mouse liver tissue extract.

AMID (S-20) - sc-54163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-AMID antibody - ab108527 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AMID antibody (ab108527) at 1/500 dilution + Human fetal kidney lysate

Anti-AMID antibody - ab94901 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-AMID antibody (ab94901) at 1/50 dilution + Mouse liver tissue lysates at 35 µg

Anti-AMID antibody - ab82359 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AMID antibody (ab82359) at 1/50 dilution + NCI-H460 cell line lysates at 35 µg

Anti-AMID antibody - ab115456 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115456, at 4 µg/ml, staining AMID in formalin-fixed, paraffin-embedded Human Heart tissue by Immunohistochemistry, using a biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-AMID antibody - ab57929 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-AMID antibody - ab37147 from Abcam

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab37147 stained HeLa cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab37147, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-AMID antibody - N-terminal - ab155326 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-AMID antibody - N-terminal (ab155326) at 1/1500 dilution + HepG2 cell lysate at 30 µg

Anti-AMID / AIFM2 Antibody (aa2-13) IHC-plus™ - LS-B3000 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-AIFM2 / AMID antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3000 concentration 4 ug/ml.

Anti-AMID / AIFM2 Antibody (aa205-233) - LS-C97777 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of AIFM2 antibody in NCI-H460 cell line lysates (35 ug/lane). AIFM2 (arrow) was detected using the purified antibody.

Anti-AMID / AIFM2 Antibody (aa141-190) - LS-C119385 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COS7 cells, using AIFM2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-AMID / AIFM2 Antibody - LS-C178425 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AMID / AIFM2 Antibody - LS-C306158 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-AMID / AIFM2 Antibody (aa170-185) IHC-plus™ - LS-B229 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-AIFM2 / AMID antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B229 concentration 5 ug/ml.

Anti-AMID / AIFM2 Antibody (clone 3A11) - LS-C139495 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A11
Immunoprecipitation of AIFM2 transfected lysate using anti-AIFM2 monoclonal antibody and Protein A Magnetic Bead.

Anti-AMID / AIFM2 Antibody (clone 2C6) - LS-C139246 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2C6
Western blot of AIFM2 expression in transfected 293T cell line by AMID monoclonal antibody (M13), clone 2C6.

Anti-AMID / AIFM2 Antibody - LS-C309370 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AMID / AIFM2 Antibody - LS-C309371 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AMID / AIFM2 Antibody (aa114-163) - LS-C200108 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HT-29 cells using AIFM2 antibody.

Anti-AMID / AIFM2 Antibody (aa319-348) - LS-C156186 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with AIFM2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-AMID / AIFM2 Antibody (C-Terminus) IHC-plus™ - LS-B4692 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-AIFM2 / AMID antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4692 concentration 5 ug/ml.
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