AIFM2
| Gene Symbol | AIFM2 |
|---|---|
| Entrez Gene | 84883 |
| Alt Symbol | AMID, PRG3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | apoptosis-inducing factor, mitochondrion-associated, 2 |
| Other Description | apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death|apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death|apoptosis-inducing factor 2|p53-responsive gene 3 protein |
| Swissprots | Q63Z39 B3KXI0 Q9BRQ8 |
| Accessions | CAE90404 EAW54376 Q9BRQ8 AF337957 AAL73229 AF506757 AAM77596 AI922797 AK027403 BAB55089 AK127353 BAG54492 BC006121 AAH06121 BC023601 AAH23601 BG332787 BP331371 BX537621 CAH56481 DQ893092 ABM84018 DQ896364 ABM87363 NM_032797 NP_116186 NM_001198696 NP_001185625 |
| Function | Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:12135761, ECO:0000269|PubMed:15958387}. |
| Subcellular Location | Cytoplasm. Mitochondrion outer membrane. |
| Tissue Specificity | Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. {ECO:0000269|PubMed:12135761}. |
Human AMID protein fragment - ab164677 from Abcam
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Human AMID protein fragment - ab164678 from Abcam
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AMID / AIFM2 Antibody Blocking Peptide - LS-E2525 from LifeSpan Bioscience
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AMID / AIFM2 Antibody Blocking Peptide - LS-E2524 from LifeSpan Bioscience
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AMID / AIFM2 Antibody Blocking Peptide - LS-E10627 from LifeSpan Bioscience
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AMID / AIFM2 Antibody Blocking Peptide - LS-E25818 from LifeSpan Bioscience
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Recombinant Human AMID Protein - H00084883-Q01 from Novus Biologicals
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AMID Partial Recombinant Protein - H00084883-Q02 from Novus Biologicals
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AIFM2-Antibody-Center-Blocking-Peptide - BP1355c from Abgent, a WuXi AppTec company
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AIFM2-Antibody-C-term-Blocking-Peptide - BP1355b from Abgent, a WuXi AppTec company
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AMID blocking peptide - GTX89595-PEP from GeneTex
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AIFM2 Immunizing peptide - orb17032 from Biorbyt
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AIFM2 Blocking Peptide - 33R-3161 from Fitzgerald
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AMID Peptide - AC21-0651-P from Abcore
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AIF2 / AIFM2 - H00084883-Q01-10 from Acris Antibodies
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AIF2 / AIFM2 - H00084883-Q01-25 from Acris Antibodies
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AIF2 / AIFM2 - H00084883-Q02 from Acris Antibodies
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AIF2 / AIFM2 - H00084883-Q02-10 from Acris Antibodies
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AIF2 / AIFM2 - H00084883-Q02-25 from Acris Antibodies
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AMID Peptide - 45-248P from ProSci
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AIFM2 fusion protein - Ag13412 from Proteintech Group
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Recombinant Human AIFM2, GST-tagged - AIFM2-9504H from Creative Biomart
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Recombinant Human Apoptosis-inducing factor 2(AIFM2) - CSB-YP874794HU CSB-EP874794HU CSB-BP874794HU CSB-MP874794HU from Cusabio
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AIF2 / AIFM2 - TP304934 from Acris Antibodies
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Apoptosis-inducing factor 2 (AIFM2), Recombinant Protein - MBS1122664 from MyBioSource
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