| Gene Symbol |
AIFM2
|
| Entrez Gene |
84883
|
| Alt Symbol |
AMID, PRG3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apoptosis-inducing factor, mitochondrion-associated, 2
|
| Other Description |
apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death|apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death|apoptosis-inducing factor 2|p53-responsive gene 3 protein
|
| Swissprots |
Q63Z39 B3KXI0 Q9BRQ8
|
| Accessions |
CAE90404 EAW54376 Q9BRQ8 AF337957 AAL73229 AF506757 AAM77596 AI922797 AK027403 BAB55089 AK127353 BAG54492 BC006121 AAH06121 BC023601 AAH23601 BG332787 BP331371 BX537621 CAH56481 DQ893092 ABM84018 DQ896364 ABM87363 NM_032797 NP_116186 NM_001198696 NP_001185625
|
| Function |
Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:12135761, ECO:0000269|PubMed:15958387}.
|
| Subcellular Location |
Cytoplasm. Mitochondrion outer membrane.
|
| Tissue Specificity |
Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. {ECO:0000269|PubMed:12135761}.
|