| Gene Symbol | MGAT5B |
|---|---|
| Entrez Gene | 146664 |
| Alt Symbol | GnT-IX, GnT-VB |
| Species | Human |
| Gene Type | protein-coding |
| Description | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B |
| Other Description | N-acetylglucosaminyl-transferase Vb|N-acetylglucosaminyltransferase IX|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B|alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B|beta(1,6)-N-acetylglucosaminyltransferase V|glcNAc-T Vb|hGnTVb|mannoside acetylglucosaminyltransferase 5B|mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B |
| Swissprots | Q76D04 Q96LS2 Q766X5 Q6P3S8 Q6P6B3 Q3V5L5 |
| Accessions | EAW89457 EAW89458 EAW89459 EAW89460 Q3V5L5 AB109185 BAC84969 AB114297 BAD02406 AB235153 BAE44474 AK123189 AW191036 BC036948 BC041577 BC062354 AAH62354 BC063862 AAH63862 BC144361 BC156823 AAI56824 HG509473 HG509474 HG509475 XM_005257065 XP_005257122 XM_006721707 XP_006721770 XM_011524348 XP_011522650 XM_011524349 XP_011522651 XM_011524350 XP_011522652 XM_011524351 XP_011522653 XM_011524352 XP_011522654 XM_011524353 XP_011522655 XM_011524354 XP_011522656 XR_934377 NM_001199172 NP_001186101 NM_144677 NP_653278 NM_198955 NP_945193 |
| Function | Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. {ECO:0000269|PubMed:12941944, ECO:0000269|PubMed:14617637, ECO:0000269|PubMed:14623122, ECO:0000269|PubMed:16606368, ECO:0000269|PubMed:16857188}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Predominantly expressed in brain. Expressed in all area of the adult and fetal brain Also expressed at much lower level in testis, spleen and thymus. {ECO:0000269|PubMed:12941944, ECO:0000269|PubMed:14623122}. |
| Top Pathways | N-Glycan biosynthesis, Other types of O-glycan biosynthesis |
Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), Human, ELISA Kit - E01A1917 from ARP American Research Products
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Alpha 1, 6 mannosylglycoprotein 6 beta N acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7204485 from MyBioSource
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Alpha 1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7238463 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7233059 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7228976 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7232312 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7246413 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7211646 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7238534 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7215255 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7215549 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7223002 from MyBioSource
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Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B), ELISA Kit - MBS7215589 from MyBioSource
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mannosyl (alpha-1, 6-) -glycoprotein beta-1, 6-N-acetyl-glucosaminyltransferase, isozyme B, ELISA Kit - MBS9341991 from MyBioSource
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Human MGAT5B ELISA Kit - E001454 from Biobool
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Human Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B) ELISA Kit - AE33583HU from ARP American Research Products
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