| Gene Symbol |
MGAT5B
|
| Entrez Gene |
146664
|
| Alt Symbol |
GnT-IX, GnT-VB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
|
| Other Description |
N-acetylglucosaminyl-transferase Vb|N-acetylglucosaminyltransferase IX|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B|alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B|beta(1,6)-N-acetylglucosaminyltransferase V|glcNAc-T Vb|hGnTVb|mannoside acetylglucosaminyltransferase 5B|mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B
|
| Swissprots |
Q76D04 Q96LS2 Q766X5 Q6P3S8 Q6P6B3 Q3V5L5
|
| Accessions |
EAW89457 EAW89458 EAW89459 EAW89460 Q3V5L5 AB109185 BAC84969 AB114297 BAD02406 AB235153 BAE44474 AK123189 AW191036 BC036948 BC041577 BC062354 AAH62354 BC063862 AAH63862 BC144361 BC156823 AAI56824 HG509473 HG509474 HG509475 XM_005257065 XP_005257122 XM_006721707 XP_006721770 XM_011524348 XP_011522650 XM_011524349 XP_011522651 XM_011524350 XP_011522652 XM_011524351 XP_011522653 XM_011524352 XP_011522654 XM_011524353 XP_011522655 XM_011524354 XP_011522656 XR_934377 NM_001199172 NP_001186101 NM_144677 NP_653278 NM_198955 NP_945193
|
| Function |
Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. {ECO:0000269|PubMed:12941944, ECO:0000269|PubMed:14617637, ECO:0000269|PubMed:14623122, ECO:0000269|PubMed:16606368, ECO:0000269|PubMed:16857188}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in brain. Expressed in all area of the adult and fetal brain Also expressed at much lower level in testis, spleen and thymus. {ECO:0000269|PubMed:12941944, ECO:0000269|PubMed:14623122}.
|
| Top Pathways |
N-Glycan biosynthesis, Other types of O-glycan biosynthesis
|