| Gene Symbol |
NOD1
|
| Entrez Gene |
10392
|
| Alt Symbol |
CARD4, CLR7.1, NLRC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nucleotide-binding oligomerization domain containing 1
|
| Other Description |
NLR family, CARD domain containing 1|caspase recruitment domain family, member 4|caspase recruitment domain-containing protein 4|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1|nucleotide-binding oligomerization domain-containing protein 1
|
| Swissprots |
Q8IWF5 B4DTU3 Q9Y239 Q549U4
|
| Accessions |
AAD43922 AAS46897 CAC33156 EAL24453 EAW93944 EAW93945 EAW93946 EAW93947 EAW93948 EAW93949 Q9Y239 AA845215 AF113925 AAD28350 AF126484 AAD29125 AK023969 BAG51242 AK300367 BAG62105 AY128682 AAM98064 AY128683 AAM98065 AY128684 AAM98066 AY128685 AAM98067 AY128686 AAM98068 AY187249 AY187250 BC020114 BC040339 AAH40339 CV569884 XM_005249568 XP_005249625 XM_005249572 XP_005249629 XM_005249576 XP_005249633 XM_006715633 XP_006715696 XM_011515079 XP_011513381 XM_011515080 XP_011513382 XM_011515081 XP_011513383 XM_011515082 XP_011513384 XM_011515083 XP_011513385 XM_011515084 XP_011513386 XM_011515085 XP_011513387 XM_011515086 XP_011513388 XM_011515087 XP_011513389 XM_011515088 XP_011513390 XR_926907 XR_926908 XR_926909 XR_926910 NM_006092 NP_006083
|
| Function |
Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection. {ECO:0000269|PubMed:11058605, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:22672233}.
|
| Subcellular Location |
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
|
| Tissue Specificity |
Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
|
| Top Pathways |
Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pertussis
|