NOD1

Gene Symbol	NOD1
Entrez Gene	10392
Alt Symbol	CARD4, CLR7.1, NLRC1
Species	Human
Gene Type	protein-coding
Description	nucleotide-binding oligomerization domain containing 1
Other Description	NLR family, CARD domain containing 1|caspase recruitment domain family, member 4|caspase recruitment domain-containing protein 4|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1|nucleotide-binding oligomerization domain-containing protein 1
Swissprots	Q8IWF5 B4DTU3 Q9Y239 Q549U4
Accessions	AAD43922 AAS46897 CAC33156 EAL24453 EAW93944 EAW93945 EAW93946 EAW93947 EAW93948 EAW93949 Q9Y239 AA845215 AF113925 AAD28350 AF126484 AAD29125 AK023969 BAG51242 AK300367 BAG62105 AY128682 AAM98064 AY128683 AAM98065 AY128684 AAM98066 AY128685 AAM98067 AY128686 AAM98068 AY187249 AY187250 BC020114 BC040339 AAH40339 CV569884 XM_005249568 XP_005249625 XM_005249572 XP_005249629 XM_005249576 XP_005249633 XM_006715633 XP_006715696 XM_011515079 XP_011513381 XM_011515080 XP_011513382 XM_011515081 XP_011513383 XM_011515082 XP_011513384 XM_011515083 XP_011513385 XM_011515084 XP_011513386 XM_011515085 XP_011513387 XM_011515086 XP_011513388 XM_011515087 XP_011513389 XM_011515088 XP_011513390 XR_926907 XR_926908 XR_926909 XR_926910 NM_006092 NP_006083
Function	Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection. {ECO:0000269|PubMed:11058605, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:22672233}.
Subcellular Location	Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
Tissue Specificity	Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
Top Pathways	Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CARD4 protein fragment - ab126000 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

NOD1 Blocking Peptide - LS-E1232 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOD1 Antibody Blocking Peptide - LS-E6465 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOD1 Antibody Blocking Peptide - LS-E25333 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOD1 Antibody Blocking Peptide - LS-E30985 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NOD1 Antibody Blocking Peptide - LS-E9743 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NOD1 Protein - H00010392-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NOD1 Partial Recombinant Protein - H00010392-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NOD1 Protein - H00010392-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NOD1 Blocking Peptide - NBP1-76286PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

NOD1-Antibody-C-term-Blocking-peptide - BP11805b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CARD4-Antibody-C-term-Blocking-Peptide - BP8720b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human NOD1 Protein - abx068373 from Abbexa Category Protein Source E.coli Species Human

CARD4 Peptide - AC21-0161-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CARD4 / NOD1 - H00010392-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CARD4 / NOD1 - H00010392-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CARD4 / NOD1 - H00010392-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CARD4 / NOD1 - H00010392-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CARD4 / NOD1 - H00010392-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

CARD4 / NOD1 - H00010392-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CARD4 / NOD1 - H00010392-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CARD4 / NOD1 Control Peptide - AP26256CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

NOD1 Peptide - 42-460P from ProSci Category Peptide Species Human

NOD1 Peptide - 5947P from ProSci Category Peptide Species Human

NOD1 fusion protein - ag3697 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Search more