NOD1

Gene Symbol NOD1
Entrez Gene 10392
Alt Symbol CARD4, CLR7.1, NLRC1
Species Human
Gene Type protein-coding
Description nucleotide-binding oligomerization domain containing 1
Other Description NLR family, CARD domain containing 1|caspase recruitment domain family, member 4|caspase recruitment domain-containing protein 4|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1|nucleotide-binding oligomerization domain-containing protein 1
Swissprots Q8IWF5 B4DTU3 Q9Y239 Q549U4
Accessions AAD43922 AAS46897 CAC33156 EAL24453 EAW93944 EAW93945 EAW93946 EAW93947 EAW93948 EAW93949 Q9Y239 AA845215 AF113925 AAD28350 AF126484 AAD29125 AK023969 BAG51242 AK300367 BAG62105 AY128682 AAM98064 AY128683 AAM98065 AY128684 AAM98066 AY128685 AAM98067 AY128686 AAM98068 AY187249 AY187250 BC020114 BC040339 AAH40339 CV569884 XM_005249568 XP_005249625 XM_005249572 XP_005249629 XM_005249576 XP_005249633 XM_006715633 XP_006715696 XM_011515079 XP_011513381 XM_011515080 XP_011513382 XM_011515081 XP_011513383 XM_011515082 XP_011513384 XM_011515083 XP_011513385 XM_011515084 XP_011513386 XM_011515085 XP_011513387 XM_011515086 XP_011513388 XM_011515087 XP_011513389 XM_011515088 XP_011513390 XR_926907 XR_926908 XR_926909 XR_926910 NM_006092 NP_006083
Function Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection. {ECO:0000269|PubMed:11058605, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:22672233}.
Subcellular Location Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
Tissue Specificity Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
Top Pathways Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pertussis

NOD1 CRISPR/Cas9 KO Plasmid (h) - sc-402402 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOD1 HDR Plasmid (h) - sc-402402-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOD1 Double Nickase Plasmid (h) - sc-402402-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOD1 Double Nickase Plasmid (h2) - sc-402402-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOD1 CRISPR Activation Plasmid (h) - sc-402402-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOD1 CRISPR Activation Plasmid (h2) - sc-402402-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOD1 Lentiviral Activation Particles (h) - sc-402402-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOD1 Lentiviral Activation Particles (h2) - sc-402402-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOD1 siRNA (h) - sc-37279 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOD1 shRNA Plasmid (h) - sc-37279-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOD1 shRNA (h) Lentiviral Particles - sc-37279-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOD1 RNAi - H00010392-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN15393 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15393 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08181 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08181

NOD1 siRNA (Human) - CRH7041 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human NOD1 siRNA - orb267543 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NOD1 shRNA Plasmid (Human) - CHH7041 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NOD1 miRNA 3'UTR clone - MiUTR3H-08099 from Creative biogene

Species Reactivities Human
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