NOD1

Gene Symbol NOD1
Entrez Gene 10392
Alt Symbol CARD4, CLR7.1, NLRC1
Species Human
Gene Type protein-coding
Description nucleotide-binding oligomerization domain containing 1
Other Description NLR family, CARD domain containing 1|caspase recruitment domain family, member 4|caspase recruitment domain-containing protein 4|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1|nucleotide-binding oligomerization domain-containing protein 1
Swissprots Q8IWF5 B4DTU3 Q9Y239 Q549U4
Accessions AAD43922 AAS46897 CAC33156 EAL24453 EAW93944 EAW93945 EAW93946 EAW93947 EAW93948 EAW93949 Q9Y239 AA845215 AF113925 AAD28350 AF126484 AAD29125 AK023969 BAG51242 AK300367 BAG62105 AY128682 AAM98064 AY128683 AAM98065 AY128684 AAM98066 AY128685 AAM98067 AY128686 AAM98068 AY187249 AY187250 BC020114 BC040339 AAH40339 CV569884 XM_005249568 XP_005249625 XM_005249572 XP_005249629 XM_005249576 XP_005249633 XM_006715633 XP_006715696 XM_011515079 XP_011513381 XM_011515080 XP_011513382 XM_011515081 XP_011513383 XM_011515082 XP_011513384 XM_011515083 XP_011513385 XM_011515084 XP_011513386 XM_011515085 XP_011513387 XM_011515086 XP_011513388 XM_011515087 XP_011513389 XM_011515088 XP_011513390 XR_926907 XR_926908 XR_926909 XR_926910 NM_006092 NP_006083
Function Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection. {ECO:0000269|PubMed:11058605, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:22672233}.
Subcellular Location Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
Tissue Specificity Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
Top Pathways Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pertussis

Nod1 Antibody - 3545 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SR (human), 4T1 (mouse) and C6 (rat) cell lines using Nod1 Antibody.

NOD1 (B-4) - sc-398696 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NOD1 (B-4): sc-398696. Western blot analysis of NOD1 expression in non-transfected: sc-117752 (A) and human NOD1 transfected: sc-113586 (B) 293T whole cell lysates.

NOD1 (C-9) - sc-377111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NOD1 (C-9): sc-377111. Western blot analysis of NOD1 expression in non-transfected: sc-117752 (A) and human NOD1 transfected: sc-113586 (B) 293T whole cell lysates.

NOD1 (F-6) - sc-398398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NOD1 (F-6): sc-398398. Western blot analysis of NOD1 expression in non-transfected: sc-117752 (A) and human NOD1 transfected: sc-113586 (B) 293T whole cell lysates.

NOD1 (A-18) - sc-33872 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NOD1 (A-18): sc-33872. Western blot analysis of human recombinant NOD1 fusion protein.

NOD1 (E-14) - sc-22045 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NOD1 (E-14): sc-22045. Western blot analysis of Nod1 expression in non-transfected: sc-117752 (A) and human Nod1 transfected: sc-113586 (B) 293T whole cell lysates.

NOD1 (H-176) - sc-99163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NOD1 (H-176): sc-99163. Western blot analysis of NOD1 expression in non-transfected: sc-117752 (A) and human NOD1 transfected: sc-113586 (B) 293T whole cell lysates.

NOD1 (S-20) - sc-33873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NOD1 (S-20): sc-33873. Western blot analysis of human recombinant NOD1 fusion protein.

NOD1 (L-17) - sc-15144 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CARD4 antibody - ab189409 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labeling CARD4 with ab189409 at 10 µg/ml.

Anti-CARD4 antibody - ab105338 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CARD4 antibody (ab105338) at 1 µg/ml + EL4 cell lysate at 15 µgSecondaryAnti-rabbit secondary antibody

Anti-CARD4 antibody - ab97278 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CARD4 antibody (ab97278) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-CARD4 antibody - ab117711 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Small Intestine, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded tissue, stained with ab117711 at 5µg/ml.

Anti-CARD4 antibody - ab93370 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CARD4 antibody (ab93370) at 1/100 dilution + HL-60 cell lysate at 35 µg

Anti-CARD4 antibody - ab106233 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-CARD4 antibody (ab106233) at 0.5 µg/ml + Human duodenum lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-CARD4 antibody - ab168793 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-CARD4 antibody (ab168793) at 1/500 dilutionLane 1 : CARD4 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-CARD4 antibody - ab22143 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CARD4 antibody (ab22143) at 1/2500 dilutionLane 1 : CARD4 in recombinant fusion protein containing amino acids 930-949Lane 2 : fusion partner without CARD4 amino acids 930-949

Anti-CARD4 antibody - C-terminal - ab170547 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of Jurkat cells labeling CARD4 with ab170547 at 1/10 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.

Anti-CARD4 antibody - C-terminal - ab189435 from Abcam

Prices $384.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-CARD4 antibody - C-terminal (ab189435) at 1/1000 dilution + HL60 cell lysate at 35 µg

Anti-NOD1 Antibody (C-Terminus) IHC-plus™ - LS-B5325 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NOD1 antibody IHC of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5325 concentration 5 ug/ml.

Anti-NOD1 Antibody (C-Terminus, PE) - LS-C224961 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD1 Antibody (aa612-826, Biotin) - LS-C300689 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NOD1 Antibody (aa612-826, FITC) - LS-C304886 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NOD1 Antibody (C-Terminus) - LS-C327012 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD1 Antibody (aa555-584) - LS-C323389 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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