Gene Symbol | PDCD1 |
---|---|
Entrez Gene | 5133 |
Alt Symbol | CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1 |
Species | Human |
Gene Type | protein-coding |
Description | programmed cell death 1 |
Other Description | programmed cell death protein 1|protein PD-1|systemic lupus erythematosus susceptibility 2 |
Swissprots | O00517 Q8IX89 Q15116 |
Accessions | AAC41700 AAC51774 AAN64003 ABK41899 CBX51254 EAW71298 Q15116 AI928135 AK313848 BAG36577 AY206416 AAO25116 AY238517 AAO63583 AY322430 AAP85379 BC074740 AAH74740 CR988122 U64863 AAC51773 XM_006712573 XP_006712636 XM_006724986 XP_006725049 NM_005018 NP_005009 |
Function | Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors. {ECO:0000269|PubMed:21276005}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | T cell receptor signaling pathway, Cell adhesion molecules (CAMs) |