TRIM21

Gene Symbol	TRIM21
Entrez Gene	6737
Alt Symbol	RNF81, RO52, Ro/SSA, SSA, SSA1
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 21
Other Description	52 kDa Ro protein|52 kDa ribonucleoprotein autoantigen Ro/SS-A|E3 ubiquitin-protein ligase TRIM21|RING finger protein 81|SS-A|Sicca syndrome antigen A|Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)|ro(SS-A)|sjoegren syndrome type A antigen|tripartite motif-containing 21|tripartite motif-containing protein 21
Swissprots	Q96RF8 Q5XPV5 P19474
Accessions	AAA79867 AAB87094 AAK76432 CAV30717 EAW68845 P19474 AK225564 AW575137 AY742713 AAU89982 BC010861 AAH10861 BP280435 BP288941 BU594670 EU446706 ABZ92235 M34551 AAA36581 M62800 AAA36651 XM_006718283 XP_006718346 NM_003141 NP_003132
Function	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability o
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body.
Tissue Specificity	Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.
Top Pathways	Systemic lupus erythematosus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

52 kDa Ro/SSA (D-12) - sc-25351 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

52 kDa Ro/SSA (H-140) - sc-20960 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

52 kDa Ro/SSA (E-11) - sc-48430 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

52 kDa Ro/SSA (N-20) - sc-21362 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-TRIM21 antibody - ab91423 from Abcam Prices $384.00 Sizes 20 µg Host Rabbit Clonality Polyclonal

Anti-TRIM21 antibody - ab191690 from Abcam Prices $384.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRIM21 antibody - ab4369 from Abcam Prices $378.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-TRIM21 antibody - ab96800 from Abcam Prices $376.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-TRIM21 antibody - ab119895 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRIM21 antibody - ab81640 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TRIM21 antibody - ab194370 from Abcam Prices $376.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-TRIM21 antibody - ab91425 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRIM21 antibody [MM0943-39E45] - ab201628 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0943-39E45

Anti-TRIM21 / RO52 Antibody IHC-plus™ - LS-B3096 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TRIM21 / RO52 Antibody (clone 4C6) - LS-C85417 from LifeSpan Bioscience Prices $920.00 Sizes 1 ml Host Mouse Clonality Monoclonal Clone 4C6

Anti-TRIM21 / RO52 Antibody - LS-C132187 from LifeSpan Bioscience Prices $395.00 Sizes 2 ml Host Human Clonality Polyclonal

Anti-TRIM21 / RO52 Antibody (aa1-475) - LS-C132188 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-TRIM21 / RO52 Antibody (clone 2C9) - LS-C133951 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2C9

Anti-TRIM21 / RO52 Antibody (aa144-193) - LS-C80084 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TRIM21 / RO52 Antibody (aa12-262) - LS-C178741 from LifeSpan Bioscience Prices $255.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRIM21 / RO52 Antibody (C-Terminus) - LS-C80191 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRIM21 / RO52 Antibody (aa195-293, clone TS106) - LS-C191493 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone TS106

Anti-TRIM21 / RO52 Antibody (aa250-300) - LS-C289253 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TRIM21 / RO52 Antibody (aa425-475) - LS-C289255 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TRIM21 / RO52 Antibody (aa51-100) - LS-C80190 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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