| Gene Symbol | TRIM21 |
|---|---|
| Entrez Gene | 6737 |
| Alt Symbol | RNF81, RO52, Ro/SSA, SSA, SSA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tripartite motif containing 21 |
| Other Description | 52 kDa Ro protein|52 kDa ribonucleoprotein autoantigen Ro/SS-A|E3 ubiquitin-protein ligase TRIM21|RING finger protein 81|SS-A|Sicca syndrome antigen A|Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)|ro(SS-A)|sjoegren syndrome type A antigen|tripartite motif-containing 21|tripartite motif-containing protein 21 |
| Swissprots | Q96RF8 Q5XPV5 P19474 |
| Accessions | AAA79867 AAB87094 AAK76432 CAV30717 EAW68845 P19474 AK225564 AW575137 AY742713 AAU89982 BC010861 AAH10861 BP280435 BP288941 BU594670 EU446706 ABZ92235 M34551 AAA36581 M62800 AAA36651 XM_006718283 XP_006718346 NM_003141 NP_003132 |
| Function | E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability o |
| Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung. |
| Top Pathways | Systemic lupus erythematosus |