TRIM21

Gene Symbol	TRIM21
Entrez Gene	6737
Alt Symbol	RNF81, RO52, Ro/SSA, SSA, SSA1
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 21
Other Description	52 kDa Ro protein|52 kDa ribonucleoprotein autoantigen Ro/SS-A|E3 ubiquitin-protein ligase TRIM21|RING finger protein 81|SS-A|Sicca syndrome antigen A|Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)|ro(SS-A)|sjoegren syndrome type A antigen|tripartite motif-containing 21|tripartite motif-containing protein 21
Swissprots	Q96RF8 Q5XPV5 P19474
Accessions	AAA79867 AAB87094 AAK76432 CAV30717 EAW68845 P19474 AK225564 AW575137 AY742713 AAU89982 BC010861 AAH10861 BP280435 BP288941 BU594670 EU446706 ABZ92235 M34551 AAA36581 M62800 AAA36651 XM_006718283 XP_006718346 NM_003141 NP_003132
Function	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability o
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body.
Tissue Specificity	Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.
Top Pathways	Systemic lupus erythematosus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cow TRIM21 full length protein - ab136587 from Abcam Category Protein Source Native Species Bovine

Human TRIM21 full length protein - ab136590 from Abcam Category Protein Species Human

Human TRIM21 peptide - ab23028 from Abcam Category Peptide Species Human

Human TRIM21 protein fragment - ab114611 from Abcam Category Protein Source Wheat germ Species Human

TRIM21 / RO52 Antibody Blocking Peptide - LS-E25520 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM21 / RO52 Antibody Blocking Peptide - LS-E12090 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM21 / RO52 Antibody Blocking Peptide - LS-E13737 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM21/SSA1 Partial Recombinant Protein - H00006737-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SSA1 blocking peptide - GTX89811-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

RO 52 Protein (OPPA01243) - OPPA01243 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human TRIM21 protein - orb246796 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human RO-52/SS-A protein - orb81323 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

SSA 52 kDa protein - 30-1291 from Fitzgerald Category Protein Prices $1,195.00 Sizes 1 mg Source E.coli

TRIM21 protein (His tag) - 80-1385 from Fitzgerald Category Protein Prices $95.00, $495.00 Sizes 100 µg, 1 mg Source E.coli

SS-A (Ro) Protein - abx069943 from Abbexa Category Protein

SS-A (Ro) Protein - abx069944 from Abbexa Category Protein Source Bovine Thymus

SSA1 Peptide - AC21-0349-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SS-A / Ro52 / TRIM21 - H00006737-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

SS-A / Ro52 / TRIM21 - H00006737-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SS-A / Ro52 / TRIM21 - H00006737-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Tripartite Motif Containing 21 (RO52), Human Recombinant - 228-11382-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Sf9 insect cells. Species Human

Recombinant Human RO-52 - 228-11382-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Sf9 insect cells. Species Human

Recombinant Human RO-52 - 228-11382-3 from RayBiotech Category Protein Source Sf9 insect cells. Species Human

Ro52 Peptide - 46-314P from ProSci Category Peptide Species Human

TRIM21 Peptide - 7729P from ProSci Category Peptide Species Human

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