| Gene Symbol | TRIM21 |
|---|---|
| Entrez Gene | 6737 |
| Alt Symbol | RNF81, RO52, Ro/SSA, SSA, SSA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tripartite motif containing 21 |
| Other Description | 52 kDa Ro protein|52 kDa ribonucleoprotein autoantigen Ro/SS-A|E3 ubiquitin-protein ligase TRIM21|RING finger protein 81|SS-A|Sicca syndrome antigen A|Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)|ro(SS-A)|sjoegren syndrome type A antigen|tripartite motif-containing 21|tripartite motif-containing protein 21 |
| Swissprots | Q96RF8 Q5XPV5 P19474 |
| Accessions | AAA79867 AAB87094 AAK76432 CAV30717 EAW68845 P19474 AK225564 AW575137 AY742713 AAU89982 BC010861 AAH10861 BP280435 BP288941 BU594670 EU446706 ABZ92235 M34551 AAA36581 M62800 AAA36651 XM_006718283 XP_006718346 NM_003141 NP_003132 |
| Function | E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability o |
| Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung. |
| Top Pathways | Systemic lupus erythematosus |
SS-A/Ro Antibody BioAssay ELISA Kit (Human) - 204283 from USBiological Life Science
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Anti E3 ubiquitin-protein ligase TRIM21 (TRIM21) antibody, Human, ELISA kit - CSB-EQ027705HU from ARP American Research Products
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Anti-SS-A, Human, ELISA - ORG 508 from ARP American Research Products
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E3 ubiquitin-protein ligase TRIM21, TRIM21, Human, ELISA Kit - E0290h from ARP American Research Products
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SS-A/Ro antibody, Human, ELISA Kit - E01S0286 from ARP American Research Products
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Tripartite Motif-Containing Protein 21, TRIM21/RNF81, Human, ELISA Kit - YHB3077Hu from ARP American Research Products
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TRIM21 (Human) Matched Antibody Pair - H00006737-AP11 from Acris Antibodies
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Human Anti-SS-A/Ro ELISA Kit - HS0293 from NeoScientific
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Rat Anti-SS-A/Ro ELISA Kit - RS0293 from NeoScientific
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Guinea Pig Anti-SS-A/Ro ELISA Kit - GS0293 from NeoScientific
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Monkey Anti-SS-A/Ro ELISA Kit - MKS0293 from NeoScientific
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Canine Anti-SS-A/Ro ELISA Kit - CS0293 from NeoScientific
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Porcine Anti-SS-A/Ro ELISA Kit - PS0293 from NeoScientific
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Goat Anti-SS-A/Ro ELISA Kit - GTS0293 from NeoScientific
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Rabbit Anti-SS-A/Ro ELISA Kit - RTS0293 from NeoScientific
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Chicken Anti-SS-A/Ro ELISA Kit - CKS0293 from NeoScientific
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Sheep Anti-SS-A/Ro ELISA Kit - SS0293 from NeoScientific
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Anserine SS-A/Ro antibody ELISA Kit - AS0293 from NeoScientific
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SS B/La Antibody, ELISA Kit - MBS721879 from MyBioSource
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SS-A, ELISA Kit - MBS494671-ORG 508 from MyBioSource
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SS-A 52, ELISA Kit - MBS494737-ORG 652 from MyBioSource
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SS-A 60, ELISA Kit - MBS494738-ORG 660 from MyBioSource
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Ss-A/Ro Antibody, ELISA Kit - MBS026498 from MyBioSource
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Ss-A/Ro Antibody, ELISA Kit - MBS033677 from MyBioSource
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Ss-A/Ro Antibody, ELISA Kit - MBS030864 from MyBioSource
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