Gene Symbol | ZC3H12D |
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Entrez Gene | 340152 |
Alt Symbol | C6orf95, MCPIP4, TFL, dJ281H8.1, p34 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger CCCH-type containing 12D |
Other Description | Zinc finger CCCH domain-containing protein 12D|p34|probable ribonuclease ZC3H12D|transformed follicular lymphoma|tumor suppressor TFL |
Swissprots | Q6ZRW2 B9ZZQ0 B7WNU7 B9ZZP9 B2RXF4 A1L178 A2A288 |
Accessions | A2A288 CAX11886 CAX11887 AB458221 BAH28268 AB458222 BAH28269 AK090441 BAC03422 AK127932 BAC87196 BC127762 AAI27763 BC157832 AAI57833 NM_207360 NP_997243 |
Function | May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation. {ECO:0000269|PubMed:17210687, ECO:0000269|PubMed:19531561, ECO:0000305}. |
Subcellular Location | Isoform 1: Cytoplasm. Note=Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm. |
Tissue Specificity | Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines. {ECO:0000269|PubMed:19531561}. |
ZC3H12D (N-13) - sc-169841 from Santa Cruz Biotechnology
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Anti-ZC3H12D antibody - ab100862 from Abcam
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Anti-ZC3H12D antibody - C-terminal - ab136610 from Abcam
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Anti-ZC3H12D Antibody (aa389-438) - LS-C169792 from LifeSpan Bioscience
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Anti-ZC3H12D Antibody (C-Terminus) - LS-C108693 from LifeSpan Bioscience
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ZC3H12D Antibody - NBP1-91249 from Novus Biologicals
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Anti-ZC3H12D antibody produced in rabbit - SAB3500143 from Sigma-Aldrich
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Anti-ZC3H12D antibody produced in rabbit - HPA036897 from Sigma-Aldrich
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ZC3H12D Antibody - C-terminal region (ARP66503_P050) - ARP66503_P050 from Aviva Systems Biology
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ZC3H12D antibody - orb77483 from Biorbyt
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ZC3H12D antibody - orb75394 from Biorbyt
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ZC3H12D Antibody - abx037672 from Abbexa
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ZC3H12D antibody - 24991-1-AP from Acris Antibodies
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ZC3H12D (C-term) antibody - AP26202PU-N from Acris Antibodies
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ZC3H12D Antibody - 5679 from ProSci
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ZC3H12D antibody - 24991-1-AP from Proteintech Group
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ZC3H12D Antibody - 254254 from ABBIOTEC
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ZC3H12D Antibody - 25088 from Signalway Antibody
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ZC3H12D Antibody - E301565 from Enogene
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Anti-ZC3H12D (aa 389-438) polyclonal antibody - DPABH-26848 from Creative Diagnostics
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Anti-ZC3H12D (C-terminal) polyclonal antibody - DPAB-L21466 from Creative Diagnostics
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ZC3H12D Polyclonal Antibody - PA5-20929 from Thermo Fisher Scientific
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ZC3H12D, Polyclonal Antibody - MBS853787 from MyBioSource
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ZC3H12D, Polyclonal Antibody - MBS150729 from MyBioSource
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ZC3H12D Antibody - 600-401-GC7 from Rockland Immunochemicals Inc
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