| Gene Symbol |
ZC3H12D
|
| Entrez Gene |
340152
|
| Alt Symbol |
C6orf95, MCPIP4, TFL, dJ281H8.1, p34
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger CCCH-type containing 12D
|
| Other Description |
Zinc finger CCCH domain-containing protein 12D|p34|probable ribonuclease ZC3H12D|transformed follicular lymphoma|tumor suppressor TFL
|
| Swissprots |
Q6ZRW2 B9ZZQ0 B7WNU7 B9ZZP9 B2RXF4 A1L178 A2A288
|
| Accessions |
A2A288 CAX11886 CAX11887 AB458221 BAH28268 AB458222 BAH28269 AK090441 BAC03422 AK127932 BAC87196 BC127762 AAI27763 BC157832 AAI57833 NM_207360 NP_997243
|
| Function |
May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation. {ECO:0000269|PubMed:17210687, ECO:0000269|PubMed:19531561, ECO:0000305}.
|
| Subcellular Location |
Isoform 1: Cytoplasm. Note=Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.
|
| Tissue Specificity |
Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines. {ECO:0000269|PubMed:19531561}.
|