| Gene Symbol |
SSRP1
|
| Entrez Gene |
6749
|
| Alt Symbol |
FACT, FACT80, T160
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
structure specific recognition protein 1
|
| Other Description |
FACT 80 kDa subunit|FACT complex subunit SSRP1|FACTp80|chromatin-specific transcription elongation factor 80 kDa subunit|cisplatin-DNA SSRP|facilitates chromatin remodeling 80 kDa subunit|facilitates chromatin transcription complex 80 kDa subunit|facilitates chromatin transcription complex subunit SSRP1|hSSRP1|high mobility group box|recombination signal sequence recognition protein 1|structure-specific recognition protein 1
|
| Swissprots |
Q5BJG8 Q08945
|
| Accessions |
CCQ43203 EAW73734 EAW73735 Q08945 AB209132 BAD92369 BC005116 AAH05116 BC091486 AAH91486 DQ893659 ABM84585 DQ895832 ABM86758 M86737 AAA58660 XM_005274194 XP_005274251 XM_011545218 XP_011543520 NM_003146 NP_003137
|
| Function |
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional co
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
|
