TAP1

Gene Symbol	TAP1
Entrez Gene	6890
Alt Symbol	ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N
Species	Human
Gene Type	protein-coding
Description	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Other Description	ABC transporter, MHC 1|ATP-binding cassette sub-family B member 2|ATP-binding cassette, sub-family B (MDR/TAP), member 2|antigen peptide transporter 1|peptide supply factor 1|peptide transporter PSF1|peptide transporter TAP1|peptide transporter involved in antigen processing 1|really interesting new gene 4 protein|transporter associated with antigen processing|transporter, ATP-binding cassette, major histocompatibility complex, 1
Swissprots	Q16149 Q96CP4 Q03518
Accessions	AAA89080 AAB60321 AAB60322 AAM11658 AAR05812 AHW47926 AHW47943 AHW47960 AHW47977 BAA32814 CAA47025 CAA60785 CCQ42989 EAX03646 EAX03647 EAX03648 EAX03649 EAX03650 EAX03651 EAX03652 Q03518 AB012644 BAA32813 AK093980 AK123494 AK130176 AK302340 BAH13680 AK313762 BAG36500 AY523970 AAS55411 AY523971 AAS55412 BC014081 AAH14081 BX648013 DC354917 DQ896350 ABM87349 EU176425 ABW03876 L21204 AAC12902 L21205 AAC12903 L21206 AAC12904 L21207 AAC12905 L21208 AAC12906 S70256 AAD14054 S70260 S70266 AAD14055 S70274 AAD14056 S70277 X57521 CAA40740 X57522 CAA40741 NM_000593 NP_000584 NM_001292022 NP_001278951
Function	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
Top Pathways	ABC transporters, Primary immunodeficiency, Phagosome, Herpes simplex infection, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SimpleChIP ® Human TAP1 Promoter Primers - 5148 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

Human ABCB2 / TAP1 ELISA Kit (Sandwich ELISA) - LS-F8903 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.134 ng/ml Range 0.313-20 ng/ml

Antigen peptide transporter 1 (TAP1), Human, ELISA Kit - E01A2004 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Transporter Associated with Antigen Processing, TAP, Human, ELISA Kit - E-EL-H1613 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Transporter associated with antigen processing, Human, ELISA Kit - E01T0566 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Transporter Associated with Antigen Processing, TAP, Rabbit, ELISA Kit - E-EL-RB0551 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Transporter Associated with Antigen Processing, TAP, Chicken, ELISA Kit - E-EL-Ch1594 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Transporter Associated with Antigen Processing, TAP, Porcine, ELISA Kit - E-EL-P1459 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Transporter Associated with Antigen Processing, TAP, Sheep, ELISA Kit - E-EL-S0446 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Transporter Associated with Antigen Processing, TAP, Guinea Pig, ELISA Kit - E-EL-GP0093 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Transporter Associated with Antigen Processing, TAP, Monkey, ELISA Kit - E-EL-MK0887 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Antigen peptide transporter 1 (TAP1), ELISA Kit - MBS7246593 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen peptide transporter 1 (TAP1), ELISA Kit - MBS7224592 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen Peptide Transporter 1 (TAP1), ELISA Kit - MBS2023193 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human TAP1 is typically less than 0.134ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.312-20ng/mL

Antigen peptide transporter 1 (TAP1), ELISA Kit - MBS7247925 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen Peptide Transporter 1 (TAP1), ELISA Kit - MBS262454 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transporter associated with antigen processing, ELISA Kit - MBS752091 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Antigen peptide transporter 1 (TAP1), ELISA Kit - MBS7253091 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen peptide transporter 1 (TAP1), ELISA Kit - MBS7250793 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen Peptide Transporter 1 (TAP1), ELISA Kit - MBS269178 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen Peptide Transporter 1 (TAP1), ELISA Kit - MBS266108 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen Peptide Transporter 1 (TAP1), ELISA Kit - MBS263068 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen peptide transporter 1 (TAP1), ELISA Kit - MBS7222176 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen peptide transporter 1 (TAP1), ELISA Kit - MBS7250349 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antigen peptide transporter 1 (TAP1), ELISA Kit - MBS7223730 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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