TAP1

Gene Symbol	TAP1
Entrez Gene	6890
Alt Symbol	ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N
Species	Human
Gene Type	protein-coding
Description	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Other Description	ABC transporter, MHC 1\|ATP-binding cassette sub-family B member 2\|ATP-binding cassette, sub-family B (MDR/TAP), member 2\|antigen peptide transporter 1\|peptide supply factor 1\|peptide transporter PSF1\|peptide transporter TAP1\|peptide transporter involved in antigen processing 1\|really interesting new gene 4 protein\|transporter associated with antigen processing\|transporter, ATP-binding cassette, major histocompatibility complex, 1
Swissprots	Q16149 Q96CP4 Q03518
Accessions	AAA89080 AAB60321 AAB60322 AAM11658 AAR05812 AHW47926 AHW47943 AHW47960 AHW47977 BAA32814 CAA47025 CAA60785 CCQ42989 EAX03646 EAX03647 EAX03648 EAX03649 EAX03650 EAX03651 EAX03652 Q03518 AB012644 BAA32813 AK093980 AK123494 AK130176 AK302340 BAH13680 AK313762 BAG36500 AY523970 AAS55411 AY523971 AAS55412 BC014081 AAH14081 BX648013 DC354917 DQ896350 ABM87349 EU176425 ABW03876 L21204 AAC12902 L21205 AAC12903 L21206 AAC12904 L21207 AAC12905 L21208 AAC12906 S70256 AAD14054 S70260 S70266 AAD14055 S70274 AAD14056 S70277 X57521 CAA40740 X57522 CAA40741 NM_000593 NP_000584 NM_001292022 NP_001278951
Function	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
Top Pathways	ABC transporters, Primary immunodeficiency, Phagosome, Herpes simplex infection, Antigen processing and presentation

TAP1 Antibody - 12341 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HeLa and HT-29 cells, untreated (-) or treated with Human Interferon-γ (hIFN-γ) #8901 (10 ng/ml, 16 hr; +), using TAP1 Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

TAP1 (H-300) - sc-20930 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

TAP1 (H-300): sc-20930. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing cytoplasmic and membrane staining of surface epithelial cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

TAP1 (N-20) - sc-11458 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TAP1 (N-20): sc-11458. Western blot analysis of TAP1 expression in RAW 264.7 (A) and Raji (B) whole cell lysates.

Anti-TAP1 antibody - ab13516 from Abcam

Prices	$373.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TAP1 antibody - ab83817 from Abcam

Prices	$378.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling TAP1 with ab83817 at 1/100. A Cy3-conjugated donkey anti-rabbit IgG (1/200) was used as the secondary antibody. Positive staining shown in the cytoplasm of alveolar type I and II cells. Magnification: 20X. Exposure time: 0.5 - 2.0 seconds. Left - DAPI. Middle - TAP1. Right - Merge.

Anti-TAP1 antibody - ab66074 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

All lanes : Anti-TAP1 antibody (ab66074) at 1 µg/mlLane 1 : TAP1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysate. Lysates/proteins at 50 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-TAP1 antibody - ab2099 from Abcam

Prices	$372.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TAP1 antibody - ab60112 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Ab60112 (1/50-1/100) staining human TAP1 in human cancer tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma.

Anti-TAP1 antibody - ab52781 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-TAP1 antibody (ab52781) at 1/1000 dilutionLane 1 : a total protein extract from E coli with 50ng to 100 ng of a Tagged irrelevant antigen (Negative control) Lane 2 : a total protein extract from E coli with 50ng to 500ng of the antigen (Tagged fusion protein) Lysates/proteins at 20 µg per lane.SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase at 1/5000 dilution

Anti-TAP1 antibody - ab115014 from Abcam

Prices	$376.00
Sizes	200 µl
Host	Goat
Clonality	Polyclonal

Anti-TAP1 antibody (ab115014) at 1 µg/ml + MCF7 lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-TAP1 antibody [53H8] - ab10356 from Abcam

Prices	$378.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	53H8

All lanes : Anti-TAP1 antibody [53H8] (ab10356) at 5 µg/mlLane 1 : SW480 (Human colon adenocarcinoma cell line) Whole Cell Lysate Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-ABCB2 / TAP1 Antibody (C-Terminus) - LS-C330708 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ABCB2 / TAP1 Antibody (C-Terminus, PE) - LS-C283733 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ABCB2 / TAP1 Antibody - LS-C341970 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ABCB2 / TAP1 Antibody (aa504-553) - LS-C102043 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

TAP1 antibody LS-C102043 Western blot of MCF7 cell lysate.

Anti-ABCB2 / TAP1 Antibody (clone TAP1.28) - LS-C179658 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	TAP1.28

Anti-ABCB2 / TAP1 Antibody - LS-C334564 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of HepG2 cell line, using TAP1 antibody.

Anti-ABCB2 / TAP1 Antibody (clone 3D10) - LS-C139479 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3D10

Western blot of TAP1 expression in transfected 293T cell line by TAP1 monoclonal antibody (M03), clone 3D10.

Anti-ABCB2 / TAP1 Antibody (aa780-795) - LS-C3357 from LifeSpan Bioscience

Prices	$285.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ABCB2 / TAP1 Antibody (C-Terminus) - LS-C10861 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ABCB2 / TAP1 Antibody (aa735-748) - LS-C10862 from LifeSpan Bioscience

Prices	$345.00
Sizes	25 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ABCB2 / TAP1 Antibody (C-Terminus) - LS-C18748 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ABCB2 / TAP1 Antibody (C-Terminus) - LS-C42564 from LifeSpan Bioscience

Prices	$340.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ABCB2 / TAP1 Antibody (clone 53H8) - LS-C82278 from LifeSpan Bioscience

Prices	$380.00
Sizes	50 µl
Host	Mouse
Clonality	Monoclonal
Clone	53H8

Anti-ABCB2 / TAP1 Antibody (C-Terminus) - LS-C132640 from LifeSpan Bioscience

Prices	$680.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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