| Gene Symbol |
TAP1
|
| Entrez Gene |
6890
|
| Alt Symbol |
ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
|
| Other Description |
ABC transporter, MHC 1|ATP-binding cassette sub-family B member 2|ATP-binding cassette, sub-family B (MDR/TAP), member 2|antigen peptide transporter 1|peptide supply factor 1|peptide transporter PSF1|peptide transporter TAP1|peptide transporter involved in antigen processing 1|really interesting new gene 4 protein|transporter associated with antigen processing|transporter, ATP-binding cassette, major histocompatibility complex, 1
|
| Swissprots |
Q16149 Q96CP4 Q03518
|
| Accessions |
AAA89080 AAB60321 AAB60322 AAM11658 AAR05812 AHW47926 AHW47943 AHW47960 AHW47977 BAA32814 CAA47025 CAA60785 CCQ42989 EAX03646 EAX03647 EAX03648 EAX03649 EAX03650 EAX03651 EAX03652 Q03518 AB012644 BAA32813 AK093980 AK123494 AK130176 AK302340 BAH13680 AK313762 BAG36500 AY523970 AAS55411 AY523971 AAS55412 BC014081 AAH14081 BX648013 DC354917 DQ896350 ABM87349 EU176425 ABW03876 L21204 AAC12902 L21205 AAC12903 L21206 AAC12904 L21207 AAC12905 L21208 AAC12906 S70256 AAD14054 S70260 S70266 AAD14055 S70274 AAD14056 S70277 X57521 CAA40740 X57522 CAA40741 NM_000593 NP_000584 NM_001292022 NP_001278951
|
| Function |
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
|
| Top Pathways |
ABC transporters, Primary immunodeficiency, Phagosome, Herpes simplex infection, Antigen processing and presentation
|