TAP1

Gene Symbol	TAP1
Entrez Gene	6890
Alt Symbol	ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N
Species	Human
Gene Type	protein-coding
Description	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Other Description	ABC transporter, MHC 1|ATP-binding cassette sub-family B member 2|ATP-binding cassette, sub-family B (MDR/TAP), member 2|antigen peptide transporter 1|peptide supply factor 1|peptide transporter PSF1|peptide transporter TAP1|peptide transporter involved in antigen processing 1|really interesting new gene 4 protein|transporter associated with antigen processing|transporter, ATP-binding cassette, major histocompatibility complex, 1
Swissprots	Q16149 Q96CP4 Q03518
Accessions	AAA89080 AAB60321 AAB60322 AAM11658 AAR05812 AHW47926 AHW47943 AHW47960 AHW47977 BAA32814 CAA47025 CAA60785 CCQ42989 EAX03646 EAX03647 EAX03648 EAX03649 EAX03650 EAX03651 EAX03652 Q03518 AB012644 BAA32813 AK093980 AK123494 AK130176 AK302340 BAH13680 AK313762 BAG36500 AY523970 AAS55411 AY523971 AAS55412 BC014081 AAH14081 BX648013 DC354917 DQ896350 ABM87349 EU176425 ABW03876 L21204 AAC12902 L21205 AAC12903 L21206 AAC12904 L21207 AAC12905 L21208 AAC12906 S70256 AAD14054 S70260 S70266 AAD14055 S70274 AAD14056 S70277 X57521 CAA40740 X57522 CAA40741 NM_000593 NP_000584 NM_001292022 NP_001278951
Function	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
Top Pathways	ABC transporters, Primary immunodeficiency, Phagosome, Herpes simplex infection, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TAP1 CRISPR/Cas9 KO Plasmid (h) - sc-405210 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TAP1 HDR Plasmid (h) - sc-405210-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TAP1 Double Nickase Plasmid (h) - sc-405210-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TAP1 Double Nickase Plasmid (h2) - sc-405210-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TAP1 CRISPR Activation Plasmid (h) - sc-405210-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TAP1 CRISPR Activation Plasmid (h2) - sc-405210-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TAP1 Lentiviral Activation Particles (h) - sc-405210-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TAP1 Lentiviral Activation Particles (h2) - sc-405210-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TAP1 siRNA (h) - sc-42981 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TAP1 shRNA Plasmid (h) - sc-42981-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TAP1 shRNA (h) Lentiviral Particles - sc-42981-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU114421 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20997 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20997 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02947 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02947

TAP1 siRNA (Human) - CRH4718 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TAP1 RNAi - H00006890-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TAP1 - MBS8232002 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TAP1 (NM_000593.5) - SHH423012 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TAP1(NM_000593.5) - SHL055957 from Creative biogene Category siRNA Species Reactivities Human

Human TAP1 siRNA - orb265220 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TAP1 shRNA Plasmid (Human) - CHH4718 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TAP1 miRNA 3'UTR clone - MiUTR1H-10175 from Creative biogene Species Reactivities Human

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