| Gene Symbol |
MAGEA3
|
| Entrez Gene |
4102
|
| Alt Symbol |
CT1.3, HIP8, HYPD, MAGE3, MAGEA6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
melanoma antigen family A3
|
| Other Description |
MAGE-3 antigen|antigen MZ2-D|cancer/testis antigen 1.3|cancer/testis antigen family 1, member 3|melanoma antigen family A, 3|melanoma-associated antigen 3
|
| Swissprots |
Q6FHI6 P43357
|
| Accessions |
AAA17446 P43357 AK223519 BAD97239 AK292384 BAF85073 BC000340 AAH00340 BC005963 AAH05963 BC011744 AAH11744 BC016803 AAH16803 BC017389 AAH17389 CR541767 CAG46566 CR541768 CAG46567 CR541774 CAG46573 CR542020 CAG46817 DQ891850 ABM82776 DQ895040 ABM85966 XM_005274676 XP_005274733 XM_006724818 XP_006724881 XM_011531160 XP_011529462 XM_011531161 XP_011529463 NM_005362 NP_005353
|
| Function |
Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:20864041}.
|
| Tissue Specificity |
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas.
|
![Western Blot: MAGEA3 Overexpression Lysate (Adult Normal) [NBP2-07759] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MAGEA3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4349_MAGEA3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07759-img0001.jpg)