| Gene Symbol | MAGEA3 |
|---|---|
| Entrez Gene | 4102 |
| Alt Symbol | CT1.3, HIP8, HYPD, MAGE3, MAGEA6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | melanoma antigen family A3 |
| Other Description | MAGE-3 antigen|antigen MZ2-D|cancer/testis antigen 1.3|cancer/testis antigen family 1, member 3|melanoma antigen family A, 3|melanoma-associated antigen 3 |
| Swissprots | Q6FHI6 P43357 |
| Accessions | AAA17446 P43357 AK223519 BAD97239 AK292384 BAF85073 BC000340 AAH00340 BC005963 AAH05963 BC011744 AAH11744 BC016803 AAH16803 BC017389 AAH17389 CR541767 CAG46566 CR541768 CAG46567 CR541774 CAG46573 CR542020 CAG46817 DQ891850 ABM82776 DQ895040 ABM85966 XM_005274676 XP_005274733 XM_006724818 XP_006724881 XM_011531160 XP_011529462 XM_011531161 XP_011529463 NM_005362 NP_005353 |
| Function | Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:20864041}. |
| Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas. |
MAGE-A3 CRISPR/Cas9 KO Plasmid (h) - sc-402571 from Santa Cruz Biotechnology
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MAGE-A3 HDR Plasmid (h) - sc-402571-HDR from Santa Cruz Biotechnology
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MAGE-A3 Double Nickase Plasmid (h) - sc-402571-NIC from Santa Cruz Biotechnology
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MAGE-A3 Double Nickase Plasmid (h2) - sc-402571-NIC-2 from Santa Cruz Biotechnology
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MAGE-A3 CRISPR Activation Plasmid (h) - sc-402571-ACT from Santa Cruz Biotechnology
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MAGE-A3 CRISPR Activation Plasmid (h2) - sc-402571-ACT-2 from Santa Cruz Biotechnology
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MAGE-A3 Lentiviral Activation Particles (h) - sc-402571-LAC from Santa Cruz Biotechnology
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MAGE-A3 Lentiviral Activation Particles (h2) - sc-402571-LAC-2 from Santa Cruz Biotechnology
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MAGE-A3/6 siRNA (h) - sc-45284 from Santa Cruz Biotechnology
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MAGE-A3/6 shRNA Plasmid (h) - sc-45284-SH from Santa Cruz Biotechnology
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MAGE-A3/6 shRNA (h) Lentiviral Particles - sc-45284-V from Santa Cruz Biotechnology
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MAGEA3 RNAi - H00004102-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN12914 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12914 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04783 from Sigma-Aldrich
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MAGEA3 siRNA (Human) - CRH2782 from Cohesion Biosciences
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shRNA set against Human Magea3 (NM_005362.3) - SHH336747 from Creative biogene
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shRNA set against Human MAGEA3(NM_005362.3) - SHH170723 from Creative biogene
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Human MAGEA3 siRNA - orb263284 from Biorbyt
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MAGEA3 shRNA Plasmid (Human) - CHH2782 from Cohesion Biosciences
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MAGEA3 miRNA 3'UTR clone - MiUTR1H-06007 from Creative biogene
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