Plg
| Gene Symbol | Plg |
|---|---|
| Entrez Gene | 18815 |
| Alt Symbol | AI649309, Pg |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | plasminogen |
| Other Description | angiostatin|plasmin heavy chain A|plasmin light chain B |
| Swissprots | Q8CIS2 Q91WJ5 P20918 |
| Accessions | AAM22156 AAN15805 EDL02061 EDL02062 EDL02063 EDL02064 EDL02065 EDL02066 EDL02067 EDL02068 EDL02069 EDL02070 EDL02071 EDL02072 P20918 AK040840 AK132254 BAE21060 AY424276 AAR07361 BC014773 AAH14773 BC057186 AAH57186 BY131661 J04766 AAA50168 NM_008877 NP_032903 |
| Function | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000250}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity). {ECO:0000250}. |
| Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A, Neuroactive ligand-receptor interaction |
plasminogen (E-14) - sc-15036 from Santa Cruz Biotechnology
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Anti-Plasminogen antibody - ab28319 from Abcam
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Anti-Plasminogen antibody - ab28318 from Abcam
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Anti-Plasminogen antibody - ab61375 from Abcam
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Anti-Plasminogen antibody - ab61387 from Abcam
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Anti-Plasminogen antibody (Biotin) - ab48364 from Abcam
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Anti-Plasminogen antibody (FITC) - ab28414 from Abcam
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Plasminogen Antibody - NB300-544 from Novus Biologicals
![Immunocytochemistry/Immunofluorescence: Plasminogen Antibody [NB300-544] - Analysis of Angiostatin (green) showing staining in the cytoplasm of NIH-3T3 cells (right) compared to a negative control without primary antibody (left).](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_8/12499_Plasminogen-Antibody-Immunocytochemistry-Immunofluorescence-NB300-544-img0001.jpg)
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Plasminogen Antibody (RM0307-6L19) - NBP2-11853 from Novus Biologicals
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Anti -Angiostatin - A2294-07A from USBiological Life Science
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Anti -Angiostatin (ANG) - 139238 from USBiological Life Science
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Anti -Angiostatin (ANG) (AP) - 139238-AP from USBiological Life Science
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Anti -Angiostatin (ANG) (APC) - 139238-APC from USBiological Life Science
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Anti -Angiostatin (ANG) (Biotin) - 139238-Biotin from USBiological Life Science
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Anti -Angiostatin (ANG) (FITC) - 139238-FITC from USBiological Life Science
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Anti -Angiostatin (ANG) (HRP) - 139238-HRP from USBiological Life Science
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Anti -Angiostatin (ANG) (PE) - 139238-PE from USBiological Life Science
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PLMN antibody - 70R-30809 from Fitzgerald
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Angiostatin Antibody - abx100433 from Abbexa
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Plasminogen Antibody - abx100634 from Abbexa
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Plasminogen Antibody - abx022407 from Abbexa
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Plasminogen / PLG antibody - AM05163PU-N from Acris Antibodies
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Plasminogen / PLG antibody - MAB0284 from Acris Antibodies
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Plasminogen / PLG antibody - MAB4872 from Acris Antibodies
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Plasminogen / PLG antibody - PAB0686 from Acris Antibodies
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