| Gene Symbol |
Plg
|
| Entrez Gene |
18815
|
| Alt Symbol |
AI649309, Pg
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
plasminogen
|
| Other Description |
angiostatin|plasmin heavy chain A|plasmin light chain B
|
| Swissprots |
Q8CIS2 Q91WJ5 P20918
|
| Accessions |
AAM22156 AAN15805 EDL02061 EDL02062 EDL02063 EDL02064 EDL02065 EDL02066 EDL02067 EDL02068 EDL02069 EDL02070 EDL02071 EDL02072 P20918 AK040840 AK132254 BAE21060 AY424276 AAR07361 BC014773 AAH14773 BC057186 AAH57186 BY131661 J04766 AAA50168 NM_008877 NP_032903
|
| Function |
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity). {ECO:0000250}.
|
| Top Pathways |
Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A, Neuroactive ligand-receptor interaction
|