PTGS1

Gene Symbol	PTGS1
Entrez Gene	5742
Alt Symbol	COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Species	Human
Gene Type	protein-coding
Description	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Other Description	PGH synthase 1|cyclooxygenase-1|prostaglandin G/H synthase 1|prostaglandin H2 synthase 1
Swissprots	B4DHQ2 Q5T7T7 Q15122 Q5T7T8 Q5T7T6 Q3HY28 Q3HY29 P23219 B4E2S5 A8K1V7
Accessions	AAA36439 AAL33601 AAR08907 CAY39332 CAY39333 CBX54354 EAW87529 EAW87530 P23219 AF086438 AF129755 AI813317 AJ420464 AK290022 BAF82711 AK295221 BAG58214 AK304403 BAG65237 AK308222 BC029840 AAH29840 CD014048 CD014049 DA392280 DQ180740 ABA60097 DQ180741 ABA60098 DQ180742 ABA60099 DQ892441 ABM83367 DQ895652 ABM86578 HG502401 M59979 AAA03630 S36219 AAB22216 S36271 AAB22217 S78220 AAB21215 U63846 AAC50632 XM_005252105 XP_005252162 XM_011518875 XP_011517177 XM_011518876 XP_011517178 NM_000962 NP_000953 NM_001271164 NP_001258093 NM_001271165 NP_001258094 NM_001271166 NP_001258095 NM_001271367 NP_001258296 NM_001271368 NP_001258297 NM_080591 NP_542158
Function	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Subcellular Location	Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Top Pathways	Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat PTGS1 / COX-1 ELISA Kit (Sandwich ELISA) - LS-F4537 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.266 ng/ml Range 0.625-40 ng/ml

Human PTGS1 / COX-1 ELISA Kit (Sandwich ELISA) - LS-F4536 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.274 ng/ml Range 0.625-40 ng/ml

Human PTGS1 / COX-1 ELISA Kit (Cell-Based ELISA) - LS-F1907 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.625-40 ng/ml

Human PTGS1 / COX-1 ELISA Kit (Sandwich ELISA) - LS-F12317 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.625-40 ng/ml

Rat PTGS1 / COX-1 ELISA Kit (Sandwich ELISA) - LS-F12318 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 0.625-40 ng/ml

COX-1 Fluorometric Assay Kit - KA0323 from Novus Biologicals Category Assay Kit Prices $599.00 Sizes 1 kit

Human Cyclooxygenase-1 ELISA Kit - abx052485 from Abbexa Category ELISA Kit Sensitivity 0.01 ng/ml Range 0.1 ng/ml - 8 ng/ml

Prostaglandin Endoperoxide Synthase 2 (PTGS2), Human, ELISA Kit - SEA699Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.114ng/mL Range 0.312-20ng/mL

Prostaglandin G/H synthase 1, PTGS1, Human, ELISA Kit - E0122h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Prostaglandin Endoperoxide Synthase 1, PTGS1, Human, ELISA Kit - E-EL-H1845 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Prostaglandin Endoperoxide Synthase 1, PTGS1, Mouse, ELISA Kit - E-EL-M0958 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

Prostaglandin Endoperoxide Synthase 1, PTGS1, Rat, ELISA Kit - E-EL-R0791 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Prostaglandin Endoperoxide Synthase 1, PTGS1, Rabbit, ELISA Kit - E-EL-RB0934 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Prostaglandin Endoperoxide Synthase 1, PTGS1, Chicken, ELISA Kit - E-EL-Ch2026 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Prostaglandin Endoperoxide Synthase 1, PTGS1, Porcine, ELISA Kit - E-EL-P0476 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Prostaglandin Endoperoxide Synthase 1, PTGS1, Guinea Pig, ELISA Kit - E-EL-GP0828 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Prostaglandin Endoperoxide Synthase 1, PTGS1, Monkey, ELISA Kit - E-EL-MK1314 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PTGS1 (Human) IP-WB Antibody Pair - H00005742-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human PTGS1 ELISA Kit - HP0165 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PTGS1 ELISA Kit - AP0165 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) , ELISA Kit - MBS918315 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PTGS1 is typically less than 0.195 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.78 ng/ml -50 ng/ml.

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1) , ELISA Kit - MBS930076 from MyBioSource Category ELISA Kit Prices $550.00, $795.00, $2,890.00, $5,465.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Cox1 Colorimetric Cell-Based ELISA Kit - CB5164 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human PTGS1(Prostaglandin Endoperoxide Synthase 1) ELISA Kit - E-EL-H1845 from Elabscience Category ELISA Kit Sensitivity 0.38 ng/mL Range 0.63—40 ng/mL

Human PTGS1 (Prostaglandin Endoperoxide Synthase 1) CLIA Kit - E-CL-H1141 from Elabscience Category CLIA Kit Sensitivity 0.09 ng/mL Range Average Recovery (%)

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