PTGS1

Gene Symbol PTGS1
Entrez Gene 5742
Alt Symbol COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Species Human
Gene Type protein-coding
Description prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Other Description PGH synthase 1|cyclooxygenase-1|prostaglandin G/H synthase 1|prostaglandin H2 synthase 1
Swissprots B4DHQ2 Q5T7T7 Q15122 Q5T7T8 Q5T7T6 Q3HY28 Q3HY29 P23219 B4E2S5 A8K1V7
Accessions AAA36439 AAL33601 AAR08907 CAY39332 CAY39333 CBX54354 EAW87529 EAW87530 P23219 AF086438 AF129755 AI813317 AJ420464 AK290022 BAF82711 AK295221 BAG58214 AK304403 BAG65237 AK308222 BC029840 AAH29840 CD014048 CD014049 DA392280 DQ180740 ABA60097 DQ180741 ABA60098 DQ180742 ABA60099 DQ892441 ABM83367 DQ895652 ABM86578 HG502401 M59979 AAA03630 S36219 AAB22216 S36271 AAB22217 S78220 AAB21215 U63846 AAC50632 XM_005252105 XP_005252162 XM_011518875 XP_011517177 XM_011518876 XP_011517178 NM_000962 NP_000953 NM_001271164 NP_001258093 NM_001271165 NP_001258094 NM_001271166 NP_001258095 NM_001271367 NP_001258296 NM_001271368 NP_001258297 NM_080591 NP_542158
Function Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Subcellular Location Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Top Pathways Arachidonic acid metabolism

Cox1 Antibody - 4841 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C2C12 and Neuro2A cells using Cox1 Antibody.

Cox1 (D2G6) Rabbit mAb - 9896 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2G6
Western blot analysis of extracts from C2C12 and HeLa cells using Cox1 (D2G6) Rabbit mAb.

Cox-1 (H-62) - sc-7950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cox-1 (H-62): sc-7950. Western blot analysis of Cox-1 expression in U-937 whole cell lysate.

Cox-1 (C-20) - sc-1752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Cox-1 expression in NIH/3T3 (A,C) and KNRK (B) whole cell lysates. Antibodies tested include Cox-1 (C-20): sc-1752 (A,B) and Cox-1 (M-20): sc-1754 (C).

Cox-1 (11) - sc-19998 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cox-1 (11) PE: sc-19998 PE. Intracellular FCM analysis of fixed and permeabilized U-937 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>: sc-2868.

Cox-1 (4i272) - sc-70878 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Cox-1 (4i272): sc-70878. Western blot analysis of Cox-1 expression in U-937 whole cell lysate.

Cox-1 (AS70) - sc-52757 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Cox-1 (AS70): sc-52757. Western blot analysis of Cox-1 expression in CCD-1064Sk (A), U-937 (B) whole cell lysates and human platelet extract (C) .

Cox-1 (6D317) - sc-70877 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cox-1 (6D317): sc-70877. Western blot analysis of Cox-1 expression in non-transfected 293T: sc-117752 (A), human Cox-1 transfected 293T: sc-114480 (B) and U-937 (C) whole cell lysates.

Anti-COX1 / Cyclooxygenase 1 antibody - ab53766 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-COX1 / Cyclooxygenase 1 antibody (ab53766) at 1/500 dilutionLane 1 : HuvEc cell extractLane 2 : HuvEc cell extract with immunising peptide

Anti-COX1 / Cyclooxygenase 1 antibody - ab22720 from Abcam

Host Goat
Clonality Polyclonal
IHC image of ab22720 staining in human breast carcinoma formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab22720, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-COX1 / Cyclooxygenase 1 antibody - ab2338 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Ab2338 staining (1µg/ml) of HeLa lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Anti-COX1 / Cyclooxygenase 1 antibody - ab185007 from Abcam

Prices $372.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-COX1 / Cyclooxygenase 1 antibody - ab89630 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-COX1 / Cyclooxygenase 1 antibody (ab89630) at 1 µg/ml + A431 cell lysate at 50 µg

Anti-COX1 / Cyclooxygenase 1 antibody - ab23858 from Abcam

Prices $370.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-COX1 / Cyclooxygenase 1 antibody - ab84602 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-COX1 / Cyclooxygenase 1 antibody (ab84602) at 1 µg/mlLane 1 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : HUVEC (Human Umbilical Vein Endothelial Cell) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-COX1 / Cyclooxygenase 1 antibody - ab52037 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Human esophagus carcinoma stained with Anti-COX1, ab52037 at 1/100 for 30 min at RT

Anti-COX1 / Cyclooxygenase 1 antibody - ab18820 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-COX1 / Cyclooxygenase 1 antibody [5F6/F4] - ab695 from Abcam

Prices $403.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5F6/F4
Lane 1: MM standardLane 2: Cox-1 (protein standard prepared from ram seminal vesicles, supplied by Alpha Diagnostic International)Antibody 5F6/F4: 1 µg/mlLane 1: MM standardLane 2: Cox-1 (protein standard prepared from ram seminal vesicles, supplied by Alpha Diagnostic International)Antibody 5F6/F4: 1 µg/ml

Anti-COX1 / Cyclooxygenase 1 antibody [AS70] - ab16116 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AS70

Anti-COX1 / Cyclooxygenase 1 antibody [EPR5866] - ab109025 from Abcam

Prices $397.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5866
All lanes : Anti-COX1 / Cyclooxygenase 1 antibody [EPR5866] (ab109025) at 1/1000 dilutionLane 1 : NIH3T3 cell lysateLane 2 : HACAT cell lysateLane 3 : Neuro 2a cell lysateLane 4 : C2C12 cell lysateLane 5 : A431 cell lysateLane 6 : L6 cell lysateLysates/proteins at 10 µg per lane.

Anti-COX1 / Cyclooxygenase 1 antibody [EPR5866] (Alexa Fluor® 488) - ab199027 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5866
ab199027 staining COX1/Cyclooxygenase 1 in HeLa cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab199027 at 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 2µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-COX1 / Cyclooxygenase 1 antibody [EPR5867] - ab133319 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5867
All lanes : Anti-COX1 / Cyclooxygenase 1 antibody [EPR5867] (ab133319) at 1/1000 dilutionLane 1 : C2C12 cell lysateLane 2 : A431 cell lysateLane 3 : NIH 3T3 cell lysateLane 4 : Neuro 2a cell lysateLane 5 : L6 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-COX1 / Cyclooxygenase 1 antibody, prediluted - ab52106 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Human esophagus carcinoma stained with ab52106

Anti-PTGS1 / COX1 / COX-1 Antibody - LS-C26450 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PTGS1 / COX1 / COX-1 Antibody - LS-C41650 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
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