PTGS1

Gene Symbol	PTGS1
Entrez Gene	5742
Alt Symbol	COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Species	Human
Gene Type	protein-coding
Description	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Other Description	PGH synthase 1|cyclooxygenase-1|prostaglandin G/H synthase 1|prostaglandin H2 synthase 1
Swissprots	B4DHQ2 Q5T7T7 Q15122 Q5T7T8 Q5T7T6 Q3HY28 Q3HY29 P23219 B4E2S5 A8K1V7
Accessions	AAA36439 AAL33601 AAR08907 CAY39332 CAY39333 CBX54354 EAW87529 EAW87530 P23219 AF086438 AF129755 AI813317 AJ420464 AK290022 BAF82711 AK295221 BAG58214 AK304403 BAG65237 AK308222 BC029840 AAH29840 CD014048 CD014049 DA392280 DQ180740 ABA60097 DQ180741 ABA60098 DQ180742 ABA60099 DQ892441 ABM83367 DQ895652 ABM86578 HG502401 M59979 AAA03630 S36219 AAB22216 S36271 AAB22217 S78220 AAB21215 U63846 AAC50632 XM_005252105 XP_005252162 XM_011518875 XP_011517177 XM_011518876 XP_011517178 NM_000962 NP_000953 NM_001271164 NP_001258093 NM_001271165 NP_001258094 NM_001271166 NP_001258095 NM_001271367 NP_001258296 NM_001271368 NP_001258297 NM_080591 NP_542158
Function	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Subcellular Location	Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Top Pathways	Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human COX1 / Cyclooxygenase 1 full length protein - ab159277 from Abcam Category Protein Source Wheat germ Species Human

Human COX1 / Cyclooxygenase 1 peptide - ab93495 from Abcam Category Peptide

Human COX1 / Cyclooxygenase 1 peptide - ab22901 from Abcam Category Peptide Species Human

Human COX1 / Cyclooxygenase 1 protein fragment - ab159278 from Abcam Category Protein Source Wheat germ Species Human

PTGS1 / COX1 / COX-1 Antibody Blocking Peptide - LS-E25286 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTGS1 / COX1 / COX-1 Antibody Blocking Peptide - LS-E15391 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTGS1 / COX1 / COX-1 Antibody Blocking Peptide - LS-E15392 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COX-1 Recombinant Protein - H00005742-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Recombinant Human COX-1 Protein - H00005742-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

COX1 blocking peptide - GTX89939-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

PTGS1 Blocking Peptide - 33R-3265 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTGS1 Blocking Peptide - 33R-4863 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PGHS-1 Blocking Peptide - abx063162 from Abbexa Category Peptide Species Human, Mouse, Rat

COX1 / Cyclooxygenase 1 Peptide - AC21-0114-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Cyclooxygenase 1 - H00005742-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cyclooxygenase 1 - H00005742-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cyclooxygenase 1 - H00005742-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cyclooxygenase 1 - H00005742-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Cyclooxygenase 1 Control Peptide - AP00117CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

COX-1 Peptide - 45-124P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

PTGS1 fusion protein - ag4055 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Human Cox1 Antibody - GWB-ASD037 from Genway Biotech Category Protein Prices $180.00, $300.00 Sizes 50 μg, 100 μg Source Rabbit Species Human

Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) - RPA728Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) - RPA728Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) - RPA728Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Search more