| Gene Symbol |
PTGS1
|
| Entrez Gene |
5742
|
| Alt Symbol |
COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
|
| Other Description |
PGH synthase 1|cyclooxygenase-1|prostaglandin G/H synthase 1|prostaglandin H2 synthase 1
|
| Swissprots |
B4DHQ2 Q5T7T7 Q15122 Q5T7T8 Q5T7T6 Q3HY28 Q3HY29 P23219 B4E2S5 A8K1V7
|
| Accessions |
AAA36439 AAL33601 AAR08907 CAY39332 CAY39333 CBX54354 EAW87529 EAW87530 P23219 AF086438 AF129755 AI813317 AJ420464 AK290022 BAF82711 AK295221 BAG58214 AK304403 BAG65237 AK308222 BC029840 AAH29840 CD014048 CD014049 DA392280 DQ180740 ABA60097 DQ180741 ABA60098 DQ180742 ABA60099 DQ892441 ABM83367 DQ895652 ABM86578 HG502401 M59979 AAA03630 S36219 AAB22216 S36271 AAB22217 S78220 AAB21215 U63846 AAC50632 XM_005252105 XP_005252162 XM_011518875 XP_011517177 XM_011518876 XP_011517178 NM_000962 NP_000953 NM_001271164 NP_001258093 NM_001271165 NP_001258094 NM_001271166 NP_001258095 NM_001271367 NP_001258296 NM_001271368 NP_001258297 NM_080591 NP_542158
|
| Function |
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
|
| Subcellular Location |
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
|
| Top Pathways |
Arachidonic acid metabolism
|
