Gene Symbol | NUDT3 |
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Entrez Gene | 11165 |
Alt Symbol | DIPP, DIPP-1, DIPP1 |
Species | Human |
Gene Type | protein-coding |
Description | nudix (nucleoside diphosphate linked moiety X)-type motif 3 |
Other Description | diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1|diphosphoinositol polyphosphate phosphohydrolase 1|nucleoside diphosphate-linked moiety X motif 3|nudix motif 3 |
Swissprots | O95989 B2R8N4 |
Accessions | EAX03781 O95989 AF062529 AAC83224 AF062530 AAC83225 AK313440 BAG36231 BC007727 AAH07727 BC024593 BG714472 BT019984 AAV38787 BT019985 AAV38788 CA430332 DA803962 DQ893118 ABM84044 DQ896391 ABM87390 NM_006703 NP_006694 |
Function | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate. {ECO:0000269|PubMed:9822604}. |
Subcellular Location | Cytoplasm {ECO:0000305}. |
Tissue Specificity | Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney. {ECO:0000269|PubMed:9822604}. |
NUDT3 (E-12) - sc-107828 from Santa Cruz Biotechnology
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Anti-NUDT3 antibody - ab126962 from Abcam
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Anti-NUDT3 antibody - ab56835 from Abcam
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Anti-NUDT3 Antibody - LS-C155431 from LifeSpan Bioscience
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Anti-NUDT3 Antibody (aa73-122) - LS-C170498 from LifeSpan Bioscience
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NUDT3 Antibody - NBP2-15048 from Novus Biologicals
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NUDT3 Antibody - H00011165-B01 from Novus Biologicals
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NUDT3 Antibody (3C5) - H00011165-M01 from Novus Biologicals
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Anti-NUDT3 antibody produced in rabbit - SAB2700523 from Sigma-Aldrich
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Monoclonal Anti-NUDT3 antibody produced in mouse - WH0011165M1 from Sigma-Aldrich
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NUDT3 Antibody - middle region (ARP68548_P050) - ARP68548_P050 from Aviva Systems Biology
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NUDT3-Antibody-monoclonal-M01 - AT3131a from Abgent, a WuXi AppTec company
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NUDT3 antibody - GTX115595 from GeneTex
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NUDT3 / DIPP1 antibody - 20542-1-AP from Acris Antibodies
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NUDT3 / DIPP1 antibody - H00011165-B01 from Acris Antibodies
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NUDT3 / DIPP1 antibody - H00011165-M01 from Acris Antibodies
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NUDT3 antibody - 20542-1-AP from Proteintech Group
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Anti-NUDT3 (aa 73-122) polyclonal antibody - DPABH-02909 from Creative Diagnostics
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Anti-NUDT3 (full length) polyclonal antibody - DPABH-10028 from Creative Diagnostics
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Anti-NUDT3 (aa 1-156) polyclonal antibody - DPABH-23035 from Creative Diagnostics
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NUDT3 Polyclonal Antibody - PA5-30435 from Thermo Fisher Scientific
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NUDT3 - MBS271881 from MyBioSource
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Anti-nudix (nucleoside diphosphate linked moiety X)-type motif 3 - 08A011165 from MP Biomedicals
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NUDT3-Antibody-middle-region-AI15627 - AI15627 from Abgent, a WuXi AppTec company
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NUDT3 / DIPP1 antibody - TA332026 from Acris Antibodies
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