| Gene Symbol |
NUDT3
|
| Entrez Gene |
11165
|
| Alt Symbol |
DIPP, DIPP-1, DIPP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nudix (nucleoside diphosphate linked moiety X)-type motif 3
|
| Other Description |
diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1|diphosphoinositol polyphosphate phosphohydrolase 1|nucleoside diphosphate-linked moiety X motif 3|nudix motif 3
|
| Swissprots |
O95989 B2R8N4
|
| Accessions |
EAX03781 O95989 AF062529 AAC83224 AF062530 AAC83225 AK313440 BAG36231 BC007727 AAH07727 BC024593 BG714472 BT019984 AAV38787 BT019985 AAV38788 CA430332 DA803962 DQ893118 ABM84044 DQ896391 ABM87390 NM_006703 NP_006694
|
| Function |
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate. {ECO:0000269|PubMed:9822604}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney. {ECO:0000269|PubMed:9822604}.
|