| Gene Symbol |
RXFP2
|
| Entrez Gene |
122042
|
| Alt Symbol |
GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
relaxin/insulin-like family peptide receptor 2
|
| Other Description |
G protein coupled receptor affecting testicular descent|G-protein coupled receptor 106|G-protein coupled receptor affecting testicular descent|leucine-rich repeat-containing G protein-coupled receptor 8|leucine-rich repeat-containing G-protein coupled receptor 8|relaxin family peptide receptor 2|relaxin receptor 2
|
| Swissprots |
Q3KU23 B1ALE9 Q8WXD0
|
| Accessions |
EAX08484 EAX08485 Q8WXD0 AF403384 AAL69324 AF453828 AAL73946 AY899851 AAX85199 BC146279 AAI46280 BC148729 AAI48730 XM_011534918 XP_011533220 NM_001166058 NP_001159530 NM_130806 NP_570718
|
| Function |
Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|
![Western Blot: LGR8 Overexpression Lysate (Adult Normal) [NBL1-15638] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LGR8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1728_LGR8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15638-img0002.jpg)