Gene Symbol | RXFP2 |
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Entrez Gene | 122042 |
Alt Symbol | GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2 |
Species | Human |
Gene Type | protein-coding |
Description | relaxin/insulin-like family peptide receptor 2 |
Other Description | G protein coupled receptor affecting testicular descent|G-protein coupled receptor 106|G-protein coupled receptor affecting testicular descent|leucine-rich repeat-containing G protein-coupled receptor 8|leucine-rich repeat-containing G-protein coupled receptor 8|relaxin family peptide receptor 2|relaxin receptor 2 |
Swissprots | Q3KU23 B1ALE9 Q8WXD0 |
Accessions | EAX08484 EAX08485 Q8WXD0 AF403384 AAL69324 AF453828 AAL73946 AY899851 AAX85199 BC146279 AAI46280 BC148729 AAI48730 XM_011534918 XP_011533220 NM_001166058 NP_001159530 NM_130806 NP_570718 |
Function | Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow. |
Top Pathways | Neuroactive ligand-receptor interaction |
Relaxin Receptor 2 CRISPR/Cas9 KO Plasmid (h) - sc-408061 from Santa Cruz Biotechnology
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Relaxin Receptor 2 HDR Plasmid (h) - sc-408061-HDR from Santa Cruz Biotechnology
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Relaxin Receptor 2 Double Nickase Plasmid (h) - sc-408061-NIC from Santa Cruz Biotechnology
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Relaxin Receptor 2 Double Nickase Plasmid (h2) - sc-408061-NIC-2 from Santa Cruz Biotechnology
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Relaxin Receptor 2 CRISPR Activation Plasmid (h) - sc-408061-ACT from Santa Cruz Biotechnology
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Relaxin Receptor 2 CRISPR Activation Plasmid (h2) - sc-408061-ACT-2 from Santa Cruz Biotechnology
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Relaxin Receptor 2 Lentiviral Activation Particles (h) - sc-408061-LAC from Santa Cruz Biotechnology
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Relaxin Receptor 2 Lentiviral Activation Particles (h2) - sc-408061-LAC-2 from Santa Cruz Biotechnology
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Relaxin Receptor 2 siRNA (h) - sc-40179 from Santa Cruz Biotechnology
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Relaxin Receptor 2 shRNA Plasmid (h) - sc-40179-SH from Santa Cruz Biotechnology
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Relaxin Receptor 2 shRNA (h) Lentiviral Particles - sc-40179-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU046821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18770 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18770 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05244 from Sigma-Aldrich
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RXFP2 siRNA (Human) - CRJ4688 from Cohesion Biosciences
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Relaxin R2/LGR8 RNAi - H00122042-R02 from Novus Biologicals
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RXFP2 - MBS8213482 from MyBioSource
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shRNA set against Human Rxfp2 (NM_130806.3) - SHH400940 from Creative biogene
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RXFP2 shRNA Plasmid (Human) - CHJ4688 from Cohesion Biosciences
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RXFP2 miRNA 3'UTR clone - MiUTR1H-09094 from Creative biogene
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