IPO7

Gene Symbol IPO7
Entrez Gene 10527
Alt Symbol Imp7, RANBP7
Species Human
Gene Type protein-coding
Description importin 7
Other Description RAN-binding protein 7|importin-7
Swissprots A6NNM5 Q9NTE3 Q9H177 Q1RMF7 O95373 B2R786
Accessions CAC17609 EAW68591 EAW68592 EAW68593 O95373 AF098799 AAC68903 AK027487 BAG51331 AK027892 BAG51391 AK074908 BAG52028 AK312885 BAG35733 AL117596 AL137335 CAB70698 BC114929 AAI14930 BM980653 BX342418 DA780921 NM_006391 NP_006382
Function Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 h
Subcellular Location Cytoplasm. Nucleus.

Importin-7 (E-2) - sc-365231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Importin-7 (E-2): sc-365231. Western blot analysis of Importin-7 expression in SK-N-MC nuclear extract.

Importin-7 (E-15) - sc-55232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Importin-7 (C-16) - sc-55230 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Importin-7 (C-16): sc-55230. Western blot analysis of Importin-7 expression in non-transfected: sc-117752 (A) and mouse Importin-7 transfected: sc-178804 (B) 293T whole cell lysates and IMR-32 (C) and SK-N-MC (D) nuclear extracts.

Importin-7 (H-12) - sc-271701 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Importin-7 (H-12): sc-271701. Western blot analysis of Importin-7 expression in SK-N-MC nuclear extract.

Importin-7 (D-17) - sc-55231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Importin-7 (H-78) - sc-134913 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Importin-7 (H-78): sc-134913. Western blot analysis of Importin-7 expression in non-transfected 293T: sc-117752 (A), mouse Importin-7 transfected 293T: sc-178804 (B) and MIA PaCa-2 (C) whole cell lysates and IMR-32 (D) and SK-N-MC (E) nuclear extracts.

Importin-7 (T-19) - sc-55235 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Importin-7 (T-19): sc-55235. Western blot analysis of Importin-7 expression in IMR-32 (A) and SK-N-MC (B) nuclear extracts.

Anti-Importin 7 antibody - ab15840 from Abcam

Prices $380.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab15840 stained SW480 cells. The cells were 100% methanol fixed for 5 minutes at room temperature and then incubated in 1%BSA / 0.3M glycine in 0.1% PBS-Tween for 1hour at room temperature to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab15840 at 1µg/ml) overnight at +4°C. The secondary antibody (pseudo-colored green) was ab150133 used at a 1/1000 dilution for 1hour at room temperature. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1hour at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-Importin 7 antibody - ab96669 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Importin 7 antibody (ab96669) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

Anti-Importin 7 antibody - ab88339 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-Importin 7 antibody (ab88339) at 5 µg/ml + recombinant protein (immunogen) at 0.2 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

Anti-IPO7 / RANBP7 Antibody (aa142-169) - LS-C165265 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
IPO7 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cervix carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-IPO7 / RANBP7 Antibody (aa976-1038) - LS-C185805 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Huh7 xenograft using Importin 7 antibody at 1:100 dilution.

Anti-IPO7 / RANBP7 Antibody (aa1026-1038) IHC-plus™ - LS-B2535 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-IPO7 / Importin 7 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2535 concentration 5 ug/ml.

Anti-IPO7 / RANBP7 Antibody (aa560-609) - LS-C151848 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IPO7 / RANBP7 antibody Western Blot of MCF7.

Anti-IPO7 / RANBP7 Antibody (aa142-169, AP) - LS-C236628 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IPO7 / RANBP7 Antibody (aa142-169, APC) - LS-C236629 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IPO7 / RANBP7 Antibody (aa142-169, Biotin) - LS-C236630 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IPO7 / RANBP7 Antibody (aa142-169, FITC) - LS-C236631 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IPO7 / RANBP7 Antibody (aa142-169, PE) - LS-C236634 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IPO7 / RANBP7 Antibody (aa142-169, Azide-free, HRP) - LS-C249280 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IPO7 / RANBP7 Antibody (aa149-179) - LS-C322258 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IPO7 / RANBP7 Antibody (aa1-50) - LS-C148725 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of IOP7 in formalin-fixed, paraffin-embedded mouse spleen tissue using an isotype control (top) and LS-C148725 (bottom) at 5 ug/ml.

Anti-IPO7 / RANBP7 Antibody (aa50-100) - LS-C289448 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Importin 7 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Importin 7 used at a dilution of 1:1000 (0.2 ug/mg).

Anti-IPO7 / RANBP7 Antibody (aa200-250) - LS-C289447 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Importin 7 by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-Importin 7 used at a dilution of 1:1000 (0.2 ug/mg).

Importin-7 Antibody - NBP2-27150 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Importin-7 Antibody [NBP2-27150] - Analysis of IOP7 in MCF7 cell lysate in the 1) absence and 2) presence of immunizing peptide, and 3) RAW cell lysate using this antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
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