| Gene Symbol | IPO7 |
|---|---|
| Entrez Gene | 10527 |
| Alt Symbol | Imp7, RANBP7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | importin 7 |
| Other Description | RAN-binding protein 7|importin-7 |
| Swissprots | A6NNM5 Q9NTE3 Q9H177 Q1RMF7 O95373 B2R786 |
| Accessions | CAC17609 EAW68591 EAW68592 EAW68593 O95373 AF098799 AAC68903 AK027487 BAG51331 AK027892 BAG51391 AK074908 BAG52028 AK312885 BAG35733 AL117596 AL137335 CAB70698 BC114929 AAI14930 BM980653 BX342418 DA780921 NM_006391 NP_006382 |
| Function | Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 h |
| Subcellular Location | Cytoplasm. Nucleus. |
importin 7, ELISA Kit - MBS9321555 from MyBioSource
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Importin 7 (IPO7), ELISA Kit - MBS9312334 from MyBioSource
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Human IPO7 ELISA Kit - E019679 from Biobool
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anti-RANBP7 / Importin 7 antibody - ARG63558 from Arigo Biolaboratories
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