IPO7
| Gene Symbol | IPO7 |
|---|---|
| Entrez Gene | 10527 |
| Alt Symbol | Imp7, RANBP7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | importin 7 |
| Other Description | RAN-binding protein 7|importin-7 |
| Swissprots | A6NNM5 Q9NTE3 Q9H177 Q1RMF7 O95373 B2R786 |
| Accessions | CAC17609 EAW68591 EAW68592 EAW68593 O95373 AF098799 AAC68903 AK027487 BAG51331 AK027892 BAG51391 AK074908 BAG52028 AK312885 BAG35733 AL117596 AL137335 CAB70698 BC114929 AAI14930 BM980653 BX342418 DA780921 NM_006391 NP_006382 |
| Function | Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 h |
| Subcellular Location | Cytoplasm. Nucleus. |
Importin-7 CRISPR/Cas9 KO Plasmid (h) - sc-403562 from Santa Cruz Biotechnology
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Importin-7 HDR Plasmid (h) - sc-403562-HDR from Santa Cruz Biotechnology
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Importin-7 Double Nickase Plasmid (h) - sc-403562-NIC from Santa Cruz Biotechnology
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Importin-7 Double Nickase Plasmid (h2) - sc-403562-NIC-2 from Santa Cruz Biotechnology
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Importin-7 CRISPR Activation Plasmid (h) - sc-403562-ACT from Santa Cruz Biotechnology
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Importin-7 CRISPR Activation Plasmid (h2) - sc-403562-ACT-2 from Santa Cruz Biotechnology
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Importin-7 Lentiviral Activation Particles (h) - sc-403562-LAC from Santa Cruz Biotechnology
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Importin-7 Lentiviral Activation Particles (h2) - sc-403562-LAC-2 from Santa Cruz Biotechnology
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Importin-7 siRNA (h) - sc-62501 from Santa Cruz Biotechnology
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Importin-7 shRNA Plasmid (h) - sc-62501-SH from Santa Cruz Biotechnology
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Importin-7 shRNA (h) Lentiviral Particles - sc-62501-V from Santa Cruz Biotechnology
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Importin-7 RNAi - H00010527-R01 from Novus Biologicals
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MISSION® esiRNA - EHU118351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10733 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10733 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02723 from Sigma-Aldrich
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IPO7 siRNA (Human) - CRH7154 from Cohesion Biosciences
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IPO7 - MBS8204078 from MyBioSource
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Importin-7 CRISPR/Cas9 KO Plasmid (h2) - sc-403562-KO-2 from Santa Cruz Biotechnology
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Importin-7 HDR Plasmid (h2) - sc-403562-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human IPO7 (NM_006391.2) - SHH320189 from Creative biogene
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Human IPO7 siRNA - orb267656 from Biorbyt
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IPO7 shRNA Plasmid (Human) - CHH7154 from Cohesion Biosciences
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IPO7 miRNA 3'UTR clone - MiUTR4H-TG04555 from Creative biogene
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